| 2型糖尿病与遗传和环境因素相互关系的研究 |
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| 作者姓名： | Chen Y Zhou L Xu Y Shen H Niu J |
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| 作者单位： | 1. 225001,江苏省扬州大学旅游烹饪学院营养学系营养卫生学教研室
2. 南京医科大学公共卫生学院流行病学教研室 |
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| 摘 要： | 目的 研究2型糖尿病与遗传和环境因素的相互关系。方法 对江苏省1997年糖尿病流行病学调查中，筛选出的2型糖尿病患者154例及与其性别、年龄构成相近的正常人群对照130例进行单因素和多因素非条件logistic回归分析。结果 年龄、糖尿病阳性家族史、高血压史、腰臀比大、收缩压、女性巨大胎儿史及β3－肾上腺素能受体基因为异是2型糖尿病的危险因素，职业性体力劳动是其保护因素；遗传因素与肥胖、β3－肾上腺素能受体基因变异等危险因素共同存在时，糖尿病的发病危害性（OR）将明显增加。结论 2型糖尿病是遗传因素与环境因素共同作用的结果。
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| 关 键 词： | 2型糖尿病 遗传 环境因素 糖尿病 非胰岛素依赖型 危险因素 Logisti模型 |
| 修稿时间： | 2001年4月18日 |
A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans |
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| Chen Y,Zhou L,Xu Y,Shen H,Niu J.A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans[J].Chinese Journal of Preventive Medicine,2002,36(3):191-194. |
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| Authors: | Chen Yu Zhou Ling Xu Yaochu Shen Hongbing Niu Juying |
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| Institution: | Department of Nutriology, Tourism and Chinese Cuisine of Yangzhou University, Yangzhou 225001, China. |
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| Abstract: | OBJECTIVE: To study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans. METHODS: A case-control study based on 154 type 2 diabetes mellitus and 130 healthy controls was carried out in Jiangsu Province in 1997. RESULTS: The age, family history of diabetes mellitus, hypertension history, high waist/hip ratio (WHR), high systolic blood pressure, huge fetus history, and the genotype of beta(3)-adrenergic receptor (beta(3)-AR) were the risk factors of type 2 diabetes mellitus; while occupational physical activity was protective factor of type 2 diabetes mellitus. The risk for diabetes mellitus distinctly increased while genetic factor and obesity, beta(3)-AR mutation were coexisting. CONCLUSION: Type 2 diabetes mellitus is caused by the effect of both genetic and environmental factors. |
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| Keywords: | Diabetes mellitus mon insulin dependent Risk factors Genetice Environment Logistic models |
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