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胃癌高和低发区人群幽门螺杆菌及cagA^+和hspA^+亚型感染的研究
引用本文:张联,马峻岭.胃癌高和低发区人群幽门螺杆菌及cagA^+和hspA^+亚型感染的研究[J].中华预防医学杂志,1998,32(2):67-69.
作者姓名:张联  马峻岭
作者单位:北京医科大学临床肿瘤学院北京市肿瘤防治研究所,山东省临朐县卫生局,美国Vanderbilt大学医学院传染病学系,美国国立癌症研究所
基金项目:国家“九五”攻关课题,中美胃癌协作研究基金
摘    要:目的探讨胃癌高、低发区居民幽门螺杆菌(Hp)及cagA+、hspA+亚型感染的差异,明确Hp感染与胃癌的关系。方法用ELISA方法分别检测抗Hp的IgG和IgA抗体、抗cagA的IgG抗体、抗hspA的IgG抗体。结果胃癌高发区山东省临朐县居民Hp感染率为73.8%,明显高于低发区苍山县居民感染率(59.9%)。胃癌高发区居民HpcagA+和hspA+亚型感染率分别为50.9%和17.0%,亦明显高于低发区居民(分别为34.0%和13.2%)。此外,用13C-尿素酶呼气试验(13C-BUT)作标准评价了检测Hp抗体、cagA+及hspA+方法的灵敏性(分别是92.3%、63.2%和21.9%)和特异性(分别是71.0%、80.6%和95.2%)。Hp感染,尤其是cagA+亚型的感染与胃癌高发有明显正相关关系。结论抗Hp抗体和cagA+亚型检测方法灵敏度较高,不失为胃癌流行病学研究的良好指标。

关 键 词:螺杆菌.幽门  胃肿瘤

Studies on Infection of Helicobacter Pylori and Their Subtypes cagA and hspA in Population Living in the Areas with High and Low Incidence of Gastric Cancer
Zhang Lian ,Ma Junling,Pan Kaifeng,et al..Studies on Infection of Helicobacter Pylori and Their Subtypes cagA and hspA in Population Living in the Areas with High and Low Incidence of Gastric Cancer[J].Chinese Journal of Preventive Medicine,1998,32(2):67-69.
Authors:Zhang Lian  Ma Junling  Pan Kaifeng  
Institution:Beijing Cancer Institute and School of Oncology, Beijing Medical University.
Abstract:Objective To explore the difference in infection of Helicobacter pylori (Hp) and their subtypes cagA and hspA in the residents living in the areas with high and low incidence of gastric cancer. Methods Immunoglobulin G and A antibodies against Hp and immunoglobulin G antibodies against cagA and hspA were detected for the residents in Linqu and Cangshan Counties of Shandong Province with enzyme linked immunosorbent assay (ELISA). Results Rate of infection with Hp in the residents in Linqu County, an area with high incidence of gastric cancer, was 73.8 percent, significantly higher than that in Cangshan County (59.9%), an area with low incidence. Rates of infection with Hp cagA and hspA in the residents in Linqu County were 50.9 and 17.0 percent, respectively, also significantly higher than those in Cangshan County (34.0% and 13.2%, respectively). Sensitivities and specificities of the methods for detecting antibodies against Hp, cagA and hspA were 92.3, 63.2 and 21.9 percent and 71.0, 80.6 and 95.2 percent, respectively, evaluated with 13 C urea breath teat ( 13 C UBT). Rate of infection with Hp, especially with Hp cagA , correlated significantly with the high incidence of gastric cancer. Conclusion The methods for detecting antibodies against Hp and cagA subtype are more sensitive and can be used as better indicators in epidemiological studies on gastric cancer.
Keywords:Helicobacter pylori    Gastric tumor  
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