Serologic evidence for human ehrlichiosis in Africa |
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| Authors: | P Brouqui C Le Cam P J Kelly R Laurens A Tounkara S Sawadogo V lo-Marcel L Gondao B Faugere J Delmont A Bourgeade Prof D Raoult |
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| Institution: | (1) Unité des Rickettsies, Faculté de Médecine de la Timone, 27 Boulevard Jean Moulin, F-13385 Marseille-5, France;(2) Faculty of Veterinary Science, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe;(3) Mission de Coopération Francaise, Luanda, Angola;(4) Laboratoire National de Santé Publique, Bamako, Mali;(5) Centre de Transfusion Sanguine, Ouagadougou, Burkina Faso;(6) Ministére de la Santé, Moroni, Comores;(7) Centre de Transfusion Sanguine, Bangui, République Centrafricaine;(8) Centre de Recherche et de Formation en Médecine et Santé Tropicale, Hôpital Félix Houphöuet Boigny, Marseille, France |
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| Abstract: | Human ehrlichiosis is a recently recognized rickettsial disease. It is caused byEhrlichia chaffeensis, an intraleucocytic Gram-negative, obligate intracellular bacterium, grouped within the genusEhrlichiae. Most human cases of ehrlichiosis have been diagnosed in the USA. Two cases have been reported outside of the USA, one in Europe and one in Africa. From 1 January to 30 June 1992, 765 sera from blood donors or other asymptomatic subjects in 8 African countries, including Ivory Coast, Burkina Faso, Mali, Central African Republic, Angola, Zimbabwe, Mozambique and Commores Islands, were tested by indirect immunofluorescence for the presence ofE. chaffeensis antibodies. Positive sera were confirmed by Western immunoblotting. Only two of 765 sera tested were positive. One serum obtained from Burkina Faso had an IgG titer of 1:200 and one from Mozambique had an IgG titer of 1:80. Human ehrlichiosis seems to occur infrequently in Africa, although many more sera from additional African countries need to be evaluated. |
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| Keywords: | Africa Epidemiology Ehrlichia chaffeensis Human ehrlichiosis Seroprevalence Western immmunoblot |
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