2004年抗菌药物的使用现状

目的研究医院抗菌药物应用情况及其合理性。方法随机抽取2004年10-12月500份住院病历进行回顾性调查;对其中使用抗菌药物的421例病历的用药种类、联合用药、疗程、指征、阳性菌株耐药情况等进行统计分析。结果抗菌药物使用率98%,治疗用药31%,预防用药69%;内科系统治疗用药65%,预防用药34%;外科系统治疗用药45%,预防用药54%;抗菌药物使用539例次;预防用药中单一用药占57%、二联用药19%、术前占19%、局部占5%;治疗用药中单一用药占49%、二联用药占27%、三联7%、四联1%、局部占16%;对治疗用药的病例送检55例,送检率为28%、阳性19例、阳性率35%。结论合理使用抗菌药物的管理是一项系统工程,应加强抗菌药物应用的教育和管理。

Antibiotic Use in 2004

OBJECTIVE To survey antibiotic use and its rationality in clinical settings. METHODS Randomly selected medical records of 500 patients from Oct to Dec of 2004 were reviewed for retrospective studies.Analysis with regard to drug category combination purpose,therapeatic course,indications and resistance was conducted. RESULTS The incidence of antibiotic use was 98%,31% of which was intended for active treatment,and 69% for preventive regimen;65% of the cases in internal medicine were for active treatment,and 34% for preventive regimen,45% of the cases in surgical use were for active treatment,and 54% were for preventive purposes.The total number of antibiotic use was 539 case-times.In terms of preventive use,single drug comprised 57%,bi-drug therapy 19%,before operations 19%,and local use was 5%.As for active treatment single drug consisted of 49%,two-drugs 27%,three-drugs 7%,and four-drugs 1%,local use accounted for 16%.Fifty five cases of the therapeutic use of antibiotics were reviewed,taking up 28% of the total with 19 positive cases,whose positive rate accounted for 35%. CONCLUSIONS The administration of the reasonable use of antibiotics is a systematic project.