铜绿假单胞菌感染的分布及耐药性分析

目的 了解铜绿假单胞菌(PAE)感染的临床分布及其对常用抗菌药物的耐药性,为临床抗感染治疗提供依据.方法 回顾2008年1月- 2010年12月从临床标本中分离的PAE,分析其药敏结果.结果 从各类标本中共分离出PAE 286株,标本来源以痰、创口分泌物为主,分别占67.8％、19.6％；感染分布以ICU、呼吸内科为主,分别占32.2％、23.4％；PAE敏感率较高的药物有阿米卡星、妥布霉素、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、亚胺培南,耐药率均＜30.0％；耐药率较高的药物有头孢噻肟、磺胺甲噁唑/甲氧苄啶、庆大霉素和氨曲南,耐药率均＞50.0％.结论 临床应合理应用抗菌药物,减少耐药性的产生.

Distribution of Pseudomonas aeruginosa infections and analysis of drug resistance

OBJECTIVE To investigate the clinical distribution and the drug resistance of Pseudomonas aeruginosa infection in order to provide basis for clinical anti-infections treatment.METHODS The specimens were collected from clinical patients with infections from Jan 2008 to Dec 2010,P.aeruginosa were isolated and the drug susceptibility was tested.RESULTS A total of 286 strains P.aeruginosa isolates were isolated from various specimens.Most of P.aeruginosa were cultured from sputum(67.8%) and wound secretion(19.6%);the infections most frequently occurred in ICU(32.2%) and department of respiratory medicine(23.4%);the result of drug susceptibility testing showed that the drug susceptibility rates of PAE to amikacin,tobramycin,cefoperazone/sulbactam,piperacillin/tazobactam,and imipenem were relatively high with the drug resistance rates less than 30.0%;the resistance rates to cefotaxime,sulfamethoxazole/trimethoprim,gentamicin,and aztreonam were higher than 50.0%.CONCLUSION Rational use of antibiotics is important for the reduction of bacterial resistance.