新疆地区儿童甲型H1N1流感的临床分析

目的 分析2009年新疆地区儿童甲型H1N1流感一般情况、临床表现、实验室、影像学检测及诊断治疗特点.方法 回顾性分析2009年10月15日-12月25日新疆地区49份资料完整的儿童甲型H1N1流感病历.结果 49例均为住院患儿,重症29例,危重14例,轻型6例,分别占59.2％、28.6％和12.2％;合并症以重症肺炎为主;汉族28例,少数民族21例,分别占57.1％和42.9％;全部病例急性发病,发热为最常见症状;辅助实验室检查均有不同程度的异常变化;全部病例给予磷酸奥司他韦口服及应用抗菌药物,40例给予清热解毒中药,23例应用小剂量甲泼尼龙;治愈37例,好转5例,自动放弃4例,死亡3例,分别占75.5％、10.2％、8.2％和6.1％.结论 新疆地区儿童甲型H1N1流感重症占多数,以抗病毒为主的综合治疗是减少死亡、提高治愈率的关键.

Clinical analysis of influenza A(H1N1) infection in children in Xinjiang

OBJECTIVE To analyze the general conditions,clinical manifestations,laboratory,imaging detection and characteristics of diagnosis and treatment of influenza A(H1N1) virus infection in children in Xinjiang in 2009.METHODS The complete data of 49 children with influenza A(H1N1) virus infection in Xinjiang were retrospectively analyzed from Oct.15th to Dec.25th,2009.RESULTS The total 49 patients were hospitalized with severe symptoms in 29 cases(59.2%),critical symptoms in 14 cases(28.6%),light symptoms in 6 cases(12.2%).The main complication was severe pneumonia.Twenty-eight cases belong to Han nationality,accounting for 57.1% of the total patients,and 21 belong to the minority nationalities,accounting for 42.9%.All infections were acute and fever was the most common symptom.Auxiliary laboratory tests found different degrees of abnormal changes in all patients.All patients were orally administered with oseltamivir and antibiotics.Chinese traditional medicine was given in 40 cases and low-dose methylprednisolone was used in 23 cases.Cure was in 37 patients(75.5%),improvement in 5(10.2%),waiver in 4(8.2%),death in 3(6.1%).CONCLUSION The majority of influenza A(H1N1) infection were severe in Xinjiang,and the combined therapy mainly with anti-virus crucially reduce the mortality and improve the cure rate.