临床分离的卡他莫拉菌对抗菌药物敏感性分析

目的 探讨卡他莫拉菌(MC)的耐药现状,为临床治疗提供参考依据.方法 对临床分离的90株MC采用琼脂稀释法进行抗菌药物敏感试验,并用Nitrocefin纸片检测p内酰胺酶.结果 MC检出率最高的是儿科占56.7％,其次为呼吸内科占35.6％,肿瘤科占7.7％,MC产β-内酰胺酶率为90.0％;MC对氨苄西林的敏感率最低,仅8.9％；MC对阿莫西林/克拉维酸、左氧氟沙星和克拉霉素100.0％敏感.结论 临床医师应选用含β-内酰胺酶抑制剂的青霉素类,第二、三代头孢菌素或大环内酯类治疗MC引起的感染.

Drug susceptibility of clinical isolates of Moraxella catarrhalis

OBJECTIVE To approach the antimicrobial resistance of Moraxella catarrhalis(MCA) and provide reference for clinical treatment.METHODS The susceptibility testing was performed for 90 clinical isolates of MCA by agar dilution method.The β-lactamase was detected using nitrocefin disk.RESULTS The detection rate of MCA from department of pediatrics(56.7%) was the highest,followed by department of respiration(35.6%) and department of tumor(7.7%).90.0% of MCA isolates were β-lactamase producers.Susceptibility rate to ampicillin(8.9%) was the lowest.100.0% of MCA was sensitive to amoxicillin/clavulanic acid,levofloxacin and clarithromycin.CONCLUSION The clinician should use penicillins in combination with β-lactamase inhibitors,second and third generation cephalosporins or macrolides to treat the infection caused by MC.