北京4所医院手术患者抗菌药物应用调查分析

目的分析手术患者抗菌药物的使用现状和存在问题,保证临床安全、合理、有效地使用抗菌药物。方法采用系统抽样方法,抽取北京4所医院(友谊医院、宣武医院、天坛医院、同仁医院)2000、2004年手术患者的住院病历349、375例,对抗菌药物应用情况进行回顾性调查。结果4所医院2000、004年手术患者,分别有348、373例应用抗菌药物,使用率各为99.7%、99.5%,合理使用率各为60.9%、53.4%;其中,单纯预防性用药者分别为162、169例,各占46.6%、45.3%,预防合并治疗性用药者分别为186、204例,各占53.4%、54.7%;经验性用药分别为347、367例,各占99.7%、98.4%;联合用药中单联各占65.9%、63.5%,二联各占30.7%、32.7%,三联各占3.4%、2.9%,≥四联各占0、0.8%。结论通过两年的比较研究发现,手术患者抗菌药物的使用有不合理现象,但合理使用总体有上升趋势。

Antibiotic Application among Surgical Patients in Four Hospitals of Beijing

OBJECTIVE To perform the investigation of the status and exiting problem of antibiotic use among surgical patients in four hospitals in Beijing and provide reference for safe,rational and effective use of antibiotics clinically.METHODS The data of surgical patients(n=349 in 2000 and n=375 in 2004) were collected randomly and analyzed retrospectively.RESULTS Of the selected surgical inpatients in 2000 and 2004,99.7% and 99.5% were receiving antibiotics.The rate of rational antibiotic use was 60.9% and 53.4%,respectively.The purpose of antibiotic use was for simple prophylaxis in 46.6% and 45.3%,for both treatment and prophylaxis in 53.4% and 54.7%,respectively.The empiric use of antibiotics composed 99.7% and 98.4%,respectively.In 65.9% and 63.5%,30.7% and 32.7%,3.4% and 2.9%,0 and 0.8% of the users,a single,two,three and four or more agents were used in combinations,respectively.CONCLUSIONS There is unrational antibiotic usage in clinical practice,but the tendency of rational antibiotic use is arising in general.