胆石症患者胆汁中肠球菌属的耐药性分析

目的了解胆汁中肠球菌属各细菌的分布及其耐药情况。方法收集肝胆外科715例患者胆汁进行细菌培养、鉴定及药敏试验。结果469例中检出细菌511株,阳性率为65.6%,其中肠球菌属156株,检出率为30.5%,大肠埃希菌159株,检出率为31.3%,>2种细菌混合感染35例;药敏结果显示,粪肠球菌对青霉素及高浓度庆大霉素的耐药率明显低于屎肠球菌,粪肠球菌及屎肠球菌未见对万古霉素耐药。结论肠球菌属在胆汁中细菌检出率较高,对常见抗菌药物均存在不同程度的耐药性,对万古霉素和替考拉宁具有高度的敏感性,药敏试验结果可指导临床合理选用抗菌药物。

Drug Resistance of Enterococcus in Bile of Patients with Cholelithiasis

OBJECTIVE To analyze the resistance feature and the distribution of Enterococcus species isolated from bile specimens.METHODS Totally 715 samples of bile in intra-operation were cultured,and the drug resistances were tested.RESULTS From them 511 strains in 469 cases were detected out(65.6%),among whith 156 were Enterococcus strains and 159 were strains of Escherichia coli.The mixed infection with two kinds of germs was found in 35 cases.The results of drug susceptibility showed the resistant rates of Enterococcus faecalis to penicillin and high concentration gentamicin were lower than those of E.faecium.None of E.faecalis,and E.faecium resisted to vancomycin.CONCLUSIONS The detective rate of the Enterococcus is high in bile samples.The results reveal a different resistance to common antibiotics,but a high sensistivity to vancomycin and teicoplanin.The result of antibiotic susceptibility testing guides rational use of antibacterial agents.