常见病原菌耐药性及抗菌药物不合理应用分析

目的 探讨临床常见病原菌耐药性及抗菌药物不合理应用表现类型，为临床合理用药提供依据。方法 对2004年1月-2005年6月临床检出常见病原菌的耐药性及不合理应用抗菌药物的病例进行回顾性分析。结果 870株菌中前5种常见的病原菌分别是铜绿假单胞菌（PAE）（17．47％）、肺炎克雷伯菌（KPN）（9．66％）、鲍氏不动杆菌（ABA）（8．85％）、大肠埃希菌（ECO）（7．36％）和白色念珠菌（11．95％）；这些菌株对临床常用抗菌药物均有不同程度的耐药性；在4462份使用抗菌药物的病例中，不合理用药的病例659例，占14．77％。结论 加强抗菌药物应用管理，掌握病原菌耐药趋势，根据药敏试验结果合理应用抗菌药物，减少耐药菌的产生。

Drug-resistance of Commonly Encountered Pathogens and Irrational Use of Antibiotics

OBJECTIVE To study the drug-resistance of commonly encountered pathogens and the manifestations of irrational use of antibiotics,in order to provide the gist for clinical therapy.METHODS The retrospective analysis on the drug-resistance of commonly encountered pathogens that isolated from clinical samples and records of(irrational) use of antibiotics from Jan 2004 to Jon 2005 were carried out.RESULTS Among 870 isolates,the first five kinds of pathogens were Pseudomonas aeruginosa(17.47%),Klebsiella pneumoniae(9.66%),Acinetobacter baumannii(8.85%),Escherichia coli(7.36%)and Candida albicans(11.95%).They had resistance to the commonly used(antibiotics) in various degrees.In 4 462 records,there were 659 records of irrational use of (antibiotics),occupied 14.77%.CONCLUSIONS It is important that to strengthen the management of antibiotics(usage) and institutions in hospitals,to inform doctor the drug-resistance trend,based on the result of drug(sensitivity) test,in order to use antibiotics more rationally and reduce the appearance of drug-resistant bacteria.