铜绿假单胞菌感染分布及耐药性动态变迁

目的了解铜绿假单胞菌对多种抗菌药物耐药性的动态变迁以及感染病例科室分布,为临床治疗铜绿假单胞菌感染提供参考。方法检测758株铜绿假单胞菌对临床常用12种抗菌药物的敏感性。结果4年来铜绿假单胞菌对12种抗菌药物耐药率逐年上升,只有亚胺培南、阿米卡星等的耐药率<25.0%;铜绿假单胞菌感染主要发生在干部科(31.3%)、重症监护病房(18.2%)以及呼吸内科(17.4%);多药耐药铜绿假单胞菌共有87株,主要分布在干部科、重症监护病房、呼吸内科以及烧伤科。结论铜绿假单胞菌的耐药问题日趋严重,加强其耐药性监测可指导临床治疗,同时为临床提供最新的流行病学和耐药性变迁资料,多药耐药铜绿假单胞菌感染主要发生在长期应用抗菌药物及长时间住院的患者。

Dynamic Changes of Drug Resistance and Infectious Distribution of Pseudomonas aeruginosa

OBJECTIVE To study the dynamic changes of drug resistance and infectious distribution of Pseudomonas aeruginosa and guide drug treatment in clinic.METHODS The susceptibility to 12 antibiotics were detected in 758 P.aeruginosa strains.RESULTS The resistance of P.aeruginosa to 12 antibiotics was increased in the past four years.The resistant rate to imipenem and amikacin was below 25%.The infection caused by P.aeruginosa happened frequently in Department for Cadre,Intensive Care Units(ICU) and Department of Respiration.Among 758 strains of P.aeruginosa,87 strains were identified multi-drug resistant and found more frequently in Department for Cadre,ICU,Department of Respiration and Department of Burn.CONCLUSIONS The drug resistance of P.aeruginosa has become a more serious problem than before.The monitor of drug-resistant P.aeruginosa could guide treatment and provided epidemiologic and dynamic changes data for clinic.The infection of multi-drug resistant P.aeruginosa meets most frequently in patients who received antibiotic treatment for a long time and had a long stay in the hospital.