| 铅中毒肾损害早期检测的实验研究 |
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| 引用本文： | 安飞云,王翔朴.铅中毒肾损害早期检测的实验研究[J].中华劳动卫生职业病杂志,1990,8(4):209-211. |
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| 作者姓名： | 安飞云 王翔朴 |
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| 作者单位： | 湖南医科大学环境医学研究室
(安飞云)，湖南医科大学环境医学研究室(王翔朴) |
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| 摘 要： | 雄性大鼠腹腔注射醋酸铅5mg/kg 体重,5次/周、连续12周,肾脏出现明显的形态和功能异常。尿r-GT 活性降低是最早出现的改变,其阳性检出率也较尿蛋白、尿糖为高。表明尿r-GT 作为铅中毒肾损害的早期检测指标有一定价值,但对其特异性有待进一步研究。
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| 关 键 词： | 醋酸铅 肾损害 尿 r-GT |
Experimental Study on the Early Detection of Lead-induced Renal Damage |
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| An Fei-yun Wang Xiang-pu.Experimental Study on the Early Detection of Lead-induced Renal Damage[J].Chinese Journal of Industrial Hygiene and Occupational Diseases,1990,8(4):209-211. |
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| Authors: | An Fei-yun Wang Xiang-pu |
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| Institution: | An Fei-yun Wang Xiang-pu |
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| Abstract: | Male rats were injected ip.with lead acetate 5mg/kg body weight fivetimes a week for a period of twelve weeks.Morphologicol and functional dis-orders were revealed in the kidney of the treated animals.Decrease of the ac-tivity of r-glutamyl transpeptidase (r-GT) in urine was the earliest sigp,andits positive rate was higher than of proteinuria and glycosuria.These resultsindicated that the urinary activity of r-GT may be used as a valuable indicatorfor early detection of lead-induced renal damage,but further study is necessa-ry to assert its specificity. |
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| Keywords: | Lead acetate Renal damage Urinary r-GT |
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