急性一氧化碳中毒患者血中一氧化氮与氧及二氧化碳分压的关系

目的　探讨急性中、重度一氧化碳 (CO)中毒患者血一氧化氮 (NO)含量及其与动脉氧分压 (PaO2 )、二氧化碳分压 (PaCO2 )的关系。方法　应用硝酸还原酶法检测了急性CO中度中毒 14例、重度中毒 2 1例患者的血NO含量 ,并与PaO2 、PaCO2 进行相关分析。结果　急性中、重度CO中毒组患者血NO含量分别为 (36 .6 +9.9)、(35 .7+10 .7) μmol/L ,均明显低于对照组 (6 4 .9+14 .3)μmol/L],差异有显著性 (P <0 .0 1) ;而中度和重度中毒组间比较 ,差异无显著性 (P >0 .0 5 )。直线相关分析表明 ,急性中、重度CO中毒患者血NO含量均与PaO2 呈明显正相关 ,r值分别为 0 .92 8、0 .891,均P <0 .0 1;与PaCO2 无明显相关性。结论　急性中、重度CO中毒患者的缺氧可能是导致血NO含量减少的重要原因 ,为吸入低浓度NO治疗急性CO中毒提供了依据

Relationship between blood NO and PaO2 or PaCO2 levels of patients with acute carbon monoxide poisoning

OBJECTIVE: To investigate the relationship between blood nitrogen monoxide(NO) and PaO2 or PaCO2 levels in patients with severe and moderate acute carbon monoxide poisoning. METHOD: The blood levels of NO in patients with severe and moderate acute carbon monoxide poisoning was assayed with nitrate reductase method, and its correlation with the blood levels of PaO2 and PaCO2 was analyzed. RESULTS: The blood level of NO in patients with severe and moderate acute carbon monoxide poisoning were (36.6 +/- 9.9) and (35.7 +/- 10.7) mumol/L respectively, significantly lower than that of control group(64.9 +/- 14.3) mumol/L, P < 0.01], but there was no significant difference between moderate and severe patients(P > 0.05). The analysis of linear correlation showed that there was significant positive correlation between NO and PaO2 but not PaCO2. CONCLUSION: Anoxia of patients with acute carbon monoxide poisoning may be an important cause to reduce NO level in blood. This study provides the basis for low NO concentration inhalation in treatments of acute carbon monoxide poisoning.