首页 | 本学科首页   官方微博 | 高级检索  
检索        

我国短效口服避孕药安全性系统评估
引用本文:丁永刚,车焱,方可娟,周维谨,孙月莲,韩耀玲,Olav Meirik,Peter Faians.我国短效口服避孕药安全性系统评估[J].中国计划生育学杂志,2005,13(5):278-283.
作者姓名:丁永刚  车焱  方可娟  周维谨  孙月莲  韩耀玲  Olav Meirik  Peter Faians
作者单位:1. 上海市计划生育科学研究所,200032
2. 上海市计划生育科学研究所
3. 世界卫生组织生殖健康和研究署
摘    要:目的:评估0、1、2号片、复方左炔诺孕酮单相片和复方左炔诺孕酮三相避孕片的安全性。方法:见“我国常用口服避孕药和宫内节育器系统评估的方法概述”(中国计划生育学杂志,2005年1期17页)。结果:共检索到83篇相关文献,入选20篇。与服药前相比,国产1、2号片和复方左炔诺孕酮单相片对妇女脂代谢的某些指标有影响。与IUD相比,1号片可升高妇女的舒张压。上述脂代谢和血压的改变均无临床意义。0、1号片可能增加心血管意外的风险,但这些影响都较小。结论:国产1、2号片和复方左炔诺孕酮单相片对使用者的脂代谢和血压改变有影响,0、1号片可能增加脑血管意外风险,考虑到心血管意外在年轻健康妇女(≤35岁)中发病率很低,且被评估的短效口服药的雌激素剂量≤35μg/片,故认为被评估的短效口服避孕药对年轻健康使用者心血管疾病的绝对风险很小。

关 键 词:短效口服避孕药  系统评估  安全性
修稿时间:2004年11月11

Systematic Review of the Safety of Daily Pills in China
Ding Yonggang,Che Yan,Fang Kejuan,et al..Systematic Review of the Safety of Daily Pills in China[J].Chinese Journal of Family Planning,2005,13(5):278-283.
Authors:Ding Yonggang  Che Yan  Fang Kejuan  
Institution:Ding Yonggang,Che Yan,Fang Kejuan,et al. Shanghai Institute of Planned Parenthood Research,Shanghai 200032
Abstract:Objective: Review the safety of Pill No 0, No 1, No 2, mono-phasic levonorgestrel and tri-phasic levonorgestrel. Method: Refer to 'Methodology of systematic review of commonly-used oral contraceptives and IUDs in China' (Fang Kejuan, et al. Chinese Journal of Family Planning. 2005, 1) Results: A total of 83 relevant papers were identified, and 20 were included. Compared with per-using cycles, Pill No.1, No.2 and mono-phasic levonorgestrel had negative impact on some plasma lipids components. Compared with IUD, Pill No.1 increased women's diastolic blood pressure. The changes of plasma lipids and blood pressure did not reach clinical significance. Pill No 0 and No 1 might increase risk of cardiovascular diseases. However, all of these risks were low, particularly among the healthy young women. Conclusion: Pill No.1, No.2 and monophasic levonorgestrel have some negative impact on Chinese women's serum lipids and blood pressure. Pill No.0 and No.1 might increase risk of cardiovascular diseases. In view of healthy young women with a low background risk of cardiovascular disease and the evaluated daily pills with low dose(≤35μg/pill) of ethinylestradiol, the risk of cardiovascular disease is very low in these daily pills among healthy young users.
Keywords:Daily Pills Systematic review Safety
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号