与交通有关苯暴露同儿童白血病风险关系的meta分析

  目的  系统评价与交通有关的苯暴露与儿童白血病之间的关系。
  方法  搜索Web of Science和PubMed英文数据库，设置检索词为“childhood leukemia”或“childhood ALL”或“childhood AML”或“Benzene”或“traffic density”或“road density”和“vehicle density”，检索符合要求的相关文献，采用STATA 15.0软件对纳入的文献进行meta分析。
  结果  初次筛检文献579篇，最后纳入21篇病例对照文献研究。21个研究存在中等程度的异质性（I2=45%，P=0.014），故采取随机效应模型进行统计分析。研究结果显示，与交通有关的苯暴露对儿童白血病的风险无统计学意义（合并OR=1.03，95% CI:0.98~1.09，P=0.210）。进一步的亚组分析显示:按照Newcastle-Ottawa量表评分进行分组，≥ 7分的12项研究显示苯暴露对儿童白血病的风险有统计学意义（合并OR=1.04，95% CI:1.00~1.07，P=0.024）。漏斗图显示纳入的文献不存在出版偏倚（Begg检验，P=0.131）。
  结论  与交通有关的苯暴露与儿童患白血病之间可能不存在相关性，其结果还需要进一步的高质量前瞻性试验来验证。

Traffic related benzene exposure and childhood leukemia risk: a meta analysis

  Objective  To systematically evaluate the relationship between traffic related benzene exposure and childhood leukemia.  Methods  The English databases of web of science and PubMed were searched with the key words of "childhood leukemia", "childhood ALL", "childhood AML", "benzene", "traffic density", "road density" or "vehicle density". The relevant literatures that met the requirements were searched and meta-analysis was performed by Stata 15.0 software.  Results  A total of 579 literatures were screened and 21 case-control studies were included. There was moderate heterogeneity in 21 studies (I2=45%, P=0.014), so random effect model was used for statistical analysis. The results showed that the risk of childhood leukemia was not significantly associated to traffic related benzene exposure (pooled OR=1.03, 95% CI: 0.98-1.09, P=0.210). Further subgroup analysis showed that according to the NOS score, 12 studies with a score of ≥ 7 showed that traffic related benzene exposure had a statistically significant risk of childhood leukemia (pooled OR=1.04, 95% CI: 1.00-1.07, P=0.024). Funnel plot showed that there was no publication bias (Begg test, P=0.131).  Conclusions  There may be no correlation between traffic related benzene exposure and childhood leukemia, and the results need further high-quality prospective study to verify.