孕期铁缺乏症妇女免疫细胞活性观察

目的　分析孕期铁缺乏和缺铁性贫血 (IDA)时妇女免疫细胞功能的变化。方法　检测 12 8名铁缺乏和 5 2名正常孕妇及 5 0名孕前妇女的T淋巴细胞亚群CD 3 、CD 4 、CD 8和自然杀伤 (NK)细胞CD16活性 ,分析孕妇不同程度铁缺乏时各免疫指标的变化。结果　孕期妇女外周血T细胞亚群CD 3 、CD 4 细胞百分比及CD 4 /CD 8比值显著低于非孕育龄妇女 ;孕期妇女随着铁缺乏程度的加重 ,CD 3 、CD 4 细胞的百分比随之下降 ;IDA孕妇的CD 3 、CD 4 细胞的百分比、CD 4 /CD 8比值显著低于正常孕妇 (P <0 0 1,P <0 0 5 ,P <0 0 5 ) ;IDA孕妇CD16细胞百分比低于正常孕妇 ,但尚无显著性差异。结论　铁缺乏孕妇T细胞亚群数量改变 ,NK细胞活性的下降尚需增加样本数进一步观察

Observation on Immunologically Cell Competence of Pregnant Women with Iron Deficiency

Objective In order to review the changes in cellular immune function in pregnant women with iron deficiency.Methods T lymphocyte subsets level(CD 3?CD 4 and CD 8) and nature kill cells activity (CD 16 ) were determined in 128 iron deficiency pregant women,52 normal prenant women and 50 women before pregnancy were examined.Results The level of T lymphocyte subsets,percentages of CD 3 and CD 4 cells as well as the ratio of CD 4/CD 8 cells in the pregnant women were signficantly lower than that of those non-pregnant women.During pregnancy,with the increase of iron deficiency,the percentages of CD 3 and CD 4 cells in bodies of pregnant women decreased.The pregnant women of iron deficiency anemia(IDA) reduced percentages of CD 3 and CD 4 cells as well as the ratio of CD 4/CD 8 compared with normal pregnant women( P<0 01,P<0 05,P<0 05 );The percentage of CD 16 in pregnant women of IDA was lower than that of normal pregnant women,but no significant change.Conclusion There was significant effects of iron deficiency on T lymphocyte subsets level during pregnancy.The relationship between iron deficiency and nature kill cells activity needed to be studied further.