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大蒜素对顺铂所致大鼠肾损害的预防作用
引用本文:刘勇,仲来福.大蒜素对顺铂所致大鼠肾损害的预防作用[J].中国公共卫生,2003,19(11):1326-1328.
作者姓名:刘勇  仲来福
作者单位:大连医科大学毒理研究室,大连,116027
摘    要:目的 研究大蒜素对顺铂(CDDP)所致肾损害的预防作用及其可能机制。方法 将SD大鼠按体重随机分3组,分别为对照组(生理盐水组)、CDDP组、CDDP 大蒜素组。处理后,分别在1,3,5d测体重、肾脏系数、血清尿素氮(BUN)、肾皮质匀浆丙二醛(MDA)以及超氧化物歧化酶(SOD)活性等。结果 大蒜素预处理可减轻CDDP引起的体重降低、肾脏系数升高及BUN水平升高;能抑制CDDP引起的MDA形成增高;并能抑制CDDP引起的SOD活性下降。结论 大蒜素经口给予能预防CDDP所致的肾损害,其机制可能与其强大的抗氧化和清除自由基活性有密切关系。

关 键 词:顺铂  大蒜素  肾毒性  抗氧化作用  大鼠  肾损害  预防作用
文章编号:1001-0580(2003)11-1326-03
修稿时间:2003年4月29日

Preventive effects of allitridi on cisplatin-induced nephrotoxicity in rats
LIU Yong,ZHONG Lai-fu.Preventive effects of allitridi on cisplatin-induced nephrotoxicity in rats[J].Chinese Journal of Public Health,2003,19(11):1326-1328.
Authors:LIU Yong  ZHONG Lai-fu
Institution:LIU Yong,ZHONG Lai-fu.Department of Toxicology,Dalian Medica l University
Abstract:Objective To study the effects of allitridi on cisplatin( CDDP)-induced nephrotoxicity and explore its possible mechanisms in rats. Methods Male Sprague-Dawley rats were randomly divided in to three groups:control,CDDP ,CDDP+ allitridi.Then rats were killed on day 1,3,5 after CDDP treatment.Nephrotoxicity was assessed by measurements of body weight ,kidney index,the contents of blood urea nitrogen (BUN),changes in malondialdehy de (MDA) formation and the activity of superoxide dismutase (SOD) in kidney cort ex homogenate. Results Allitridi pretreatment would alleviate the CODP-i nduced changes of body weight,kidney index,BUN, and inhibit the increases of MDA formation in kidney cortex homogenate,and enhance the decrease of activities of SOD in kidney cortex homogenate in rats.Conclusion By oral administration,allitridi pretreatment can remarkably alleviate CDDP-induced nephrotoxicity.The mechanisms may be invol ved in antioxidation,scanvaging of free radicals,and enhancement of the activiti es of some antioxidant enzymes.
Keywords:cisplatin  allitridi  nephrotoxicity  antioxidati on
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