双生子A型人格与高血压及血生化指标研究

目的 了解双生子A型人格与高血压及血液生化指标的关系。方法 利用遗传流行病学方法对青岛市89对24岁以上双生子(同卵55对，异卵34对)进行调查。并进行A型人格测试，以比较同卵与异卵双生于A型人格得分的相关程度、A型人格及血压的一致性。推测遗传与环境因素对A型人格的影响，A型人格与高血压的关系，并探讨血液生化指标与A型人格的关系。结果 经KAPPA一致性检验，同卵(MZ)双生子之间A型人格存在着显的一致性(P＜0．001)，而异卵(DZ)双生子之间的一致性无显性差异(P＝0．802)。同时，MZ双生子之间A型人格和血压也存在显的一致性(P＜0．001)，而DZ双生子之间A型人格和血压无明显一致性(P＝0．102)。有A型人格的双生子血压的收缩压明显高于非A型人格的双生子(P＜0．05)。许多生化指标与A型人格因素相关，但是所计算出的相关系数大都小于0．30，属于弱相关。结论 MZ双生子A型人格及高血压之间存在着显的一致性，而这种一致性在DZ双生子表现不明显。A型人格是高血压的危险因素之一。A型人格与所研究血液基本生化指标之间相关较弱。

Study on relationship of type A personality of twins with hypertension and biochemical index in serum

Objective To study on tje relationship of type A personality of twin serum biochemical index of hypertension .Methods 89 twin pairs (MZ:55,DZ:34) older than 24 in Qingdao was investigated with genetic epidemiological methods.Type A personality of the twins was tested to study the correlation of the scores in MZ and DZ twins,so that the effect of genetic and environmental factors on type A personality can be studied.The relationship between type A personality and hypertension,type A personality and some serum biochemical index were also discussed.Results Significant agreement of type A personality in MZ twins was found( P <0.001),such agreement was not found in DZ twins( P =0.802).Also agreement of type A personality and hypertension was significant in MZ( P <0.001),not significant in DZ ( P =0.102).The systolic blood pressure(SBP) was higher for twins with type A personality than non-A personality twins.Some serum biochemical index was correlated with type A personality,but most of the correlation coefficients were lower than 0.30.Conclusion Agreement of type A personality and hypertension was significant in MZ,not significant in DZ.Type A personality was a risk factor for hypertension.The correlation between type A personality and basic serum biochemical index was weak.