脑梗塞遗传病因的流行病学系列研究(Ⅰ)

通过遗传流行病学病例对照方法,对宜兴市214个家系(109个脑梗塞先证家系和105个对照家系)进行分离比?多基因遗传方式和遗传度的分析?结果表明:在病例和对照家系具有良好均衡可比性的前提下,脑梗塞的分离比为0.0529,显著低于0.25,说明其不符合单基因遗传病的特征;多基因遗传方式的分析表明,其一级亲属的理论发病率为6.678%,与实际发病率8.611%相比,无统计学显著性差异,符合多基因遗传的特征;遗传度的估算显示;脑梗塞先证者的一级亲属中,遗传度为53%,其中女性亲属的遗传度达57%,显著高于男性亲属的39.4%,说明在脑梗塞病因中,遗传因素起着一定的作用,特别是对女性作用更明显?

A Series Of Studies About Genetic Agents In Arteriosclerotic Cerebral Infarction The Analyses of Heritability And Segregation Ratio

A genetic epidemiologic case-control study including 214 prdigrees( 109 cases and 105 controls)was carried out to estimate the heritability(h²)and the segregation ratio of arteriosclerotic cerebral infarcation by using the methods of Falconer and Li-Mantelfiart respeckively in Yi Xing city, March 1997. The results showed that the nuclear family members were well comparatively. The segregation ratio was 0. 0529,which was significantly less than 0.25. The theoretical incidence rate thefirst rank blood relatives in cases was 6. 678%，which was no significantly difference from actual rate (8. 611%).and P value was larger than 0.05, It means that the geneticmodel belonged to polygenetics.The heritability of the first rank blood relatives wasequal 53070(in male and female, they were respectively 39.4% and 57%).It suggested that the hereditary fact or was important in the occurance of artariosclerotic carahral infarction.