乙肝基因疫苗阻断乙肝母婴传播的效果观察

为研究乙肝基因疫苗阻断ＨＢＶ母婴传播的效果，对５６例广州市区ＨＢｓＡｇ单阳和ＨＢｓＡｇ、ＨＢｅＡｇ双阳孕妇所产婴儿按０、１、６方案全程接种乙肝基因疫苗。结果未发现一例婴儿出现不良的疫苗反应；其中对１４例单阳孕妇婴儿的保护率为１００％，而对３４例双阳孕妇婴儿为８８．２％，两率差异无显著性意义（ｕ＝１．３４Ｐ＞０．１）；全程免疫１年后随访了５４例婴儿，虽然７９．６％由母亲照料，３３．３％用母乳喂养，但均未发现病毒性乙型肝炎病例，提示乙肝基因疫苗具较高的安全和有效性，是替代乙肝血源疫苗阻断ＨＢＶ母婴传播的理想免疫制剂。

An Investigation on the Interruption of the Parental Transmission of HBV Carrier State with HB Vaccine of Gene

In order to research effect the interruption of the parental transmission of HBV by HB vaccine of gene.56 neonates born of HBsAg positive mothers and both HBsAg and HBeAg positive mothers was injected HB vaccine of gene at 0,1,6 months in Guangzhou.The result showed anyone did not find bad response after injected vaccine.Protective efficacy of 14 neonates born of HBsAg positive mothers and 34 neonates born of HBsAg and HBeAg positive mothers was respectively 100% and 88 2%.Both statistic discrepancy have not notable meaning(u=1 34,P>0 1).54 neonates was surveyed after 1 year of injected vaccine.Although 79 6% neonates take care of mothers and 33 3% neonates ate mother's milk.But did not problem with viral hepatitis B.HB vaccine of gene was proved safe and effective,and was ideal medicine to substitute HB vaccine of blood.