单纯性肥胖儿童瘦素、胰岛素及其相关性研究

目的 研究单纯性肥胖儿童瘦素、胰岛素及其相关关系。方法 对筛选出来的54名肥胖儿童和60名正常体重儿童进行瘦素、胰岛素、C-肽、血糖水平的测定，并进行相关关系的研究。结果 肥胖组儿童瘦素、胰岛素、C-肽、血糖水平高于非肥胖组儿童，胰岛素敏感性指数肥胖组儿童低于非肥胖组儿童，差异有显性意义(P＜0．05)。瘦素与体质指数、体脂百分比、体脂肪、臀围、胰岛素、C-肽浓度均呈显正相关(P＜0．05)，与血糖、瘦体重、腰臀围比没有相关性。结论 肥胖儿童存在瘦素抵抗、高胰岛素血症和胰岛素抵抗，瘦素与体质指数、胰岛素浓度呈显正相关。

Study on leptin,insulin and their relationships in simple obese children

Objective To investigate serum leptin,insulin and their relationships in the simple obese children.Methods Serum Leptin,insulin,C-peptide and fasting blood glucose were measured in 54 obese children and 60 non-obese children.At the same time,the relationship between leptin,obesity and insulin were studied.Results Leptin,insulin,C-peptide,fasting blood glucose were much higher in obese children than in non-obese ones( P <0.05),whereas insulin sensitivity index(IST) was much lower than that in non-bese children.Leptin was significantly correlated with BMI,%BF,BF,hip circumsference,insulin,C-peptide( P <0 05).Leptin was not significantly correlated with blood glucose,LBM,WHR( P >0 05).Conclusions Obese children existed leptin resistance,hyperinsulinaemia and insulin resistance.Leptin was significantly correlated with BMI,insulin.