2型糖尿病家系危险因素Logistic回归分析

目的研究家系人群中2型糖尿病(T2DM)的危险因素，为制定干预措施提供依据。方法利用葡萄糖耐量试验(OGTT)、PCR-RFLP和免疫法排除其他类型后确定了115个2型糖尿病家系，通过问卷调查和实验室检查收集危险因素的情况，并采用Logistic回归分析方法对新老2型糖尿病患者和糖耐量低减(IGT)患者危险因素进行分析。结果糖尿病患者的多因素分析显示，T2DM患者的年龄(OR=1．043，95％CI 1．024～1．062)、高血脂史(OR=4．471。95％CI 2．149～9．303)、高血压史(OR=2．075，95％CI 1．001～4．301)和腰臀比超标(OR=1．809，95％CI 1．00～4．301)是独立的危险因素，而新诊断患者仅高血压史(OR=6．068，95％ CI 1．697～21．689)是独立的危险因素，IGT患者的年龄(OR=1．398，95％CI～1．138～1．717)是危险因素。结论在本研究人群中，高血压、年龄、中心性肥胖可能是2型糖尿病的危险因素。

Logistic regresssion of risk factors in type 2 diabetes mellitus pedigrees

Objective To explore the risk factors of type 2 diabetes mellitus in T 2DM pedigrees.Methods One hundred and fifteen pedigrees of type 2 DM were diagnosed with OGTT,PCR-RFLP,GAD and ICA512.Risk factors were analyzed by Logistic regression.Results Hypertension( OR =2 075,95% CI 1 001-4 301),hyperlipidemia( OR =4 471,95% CI 2 149-9 303),high waist hip ratio( OR =1 809,95% CI 1 001-4 301) and age ( OR =1 043,95% CI 1 024-1 062), were significant in multiple-regression of risk factors in T 2DM.In new diagnosed T 2DM,hypertension( OR =6 068,95% CI 1 697-21 689) was significant.Age ( OR =1 398,95% CI 1 138-1 717) was significant in IGT.Conclusion Hypertension,age and visceral obesity were risk factors of T 2DM probably.