| p53在突变过程中的作用 |
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| 引用本文： | 李奇慧,董兆君.p53在突变过程中的作用[J].疾病控制杂志,2004,8(3):254-257. |
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| 作者姓名： | 李奇慧 董兆君 |
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| 作者单位： | 第三军医大学预防医学院,重庆,400038 |
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| 摘 要： | 肿瘤抑制基因p53在维持基因组稳定性和完整性方面发挥着重要作用。p53对突变机制和突变率都有较大的影响，p53功能缺失的各种体内外模型的突变率均有增加。突变的p53还可通过干扰包括凋亡在内的其他细胞程序而影响突变率。
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| 关 键 词： | p53 基因突变 肿瘤抑制基因 基因结构 突变频率 |
| 文章编号： | 1008-6013(2004)03-0254-04 |
| 修稿时间： | 2004年3月8日 |
Review of roles of p53 in the process of mutation |
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| LI Qi-hui,DONG Zhao-jun. School of Preventive Medicine,Third Millitary Medical University,Chongqing ,China.Review of roles of p53 in the process of mutation[J].Chinese Journal of Disease Control and Prevention,2004,8(3):254-257. |
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| Authors: | LI Qi-hui DONG Zhao-jun School of Preventive Medicine Third Millitary Medical University Chongqing China |
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| Institution: | LI Qi-hui,DONG Zhao-jun. School of Preventive Medicine,Third Millitary Medical University,Chongqing 400038,China |
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| Abstract: | The tumor suppressor gene, p53, plays an important role in preserving genomic stability and integrity. p53 affects the mechanism and frequency of mutation. The mutant frequency increased in the p53 functional loss models both in vivo and in vitro. Mutant p53 protein also interferes with other cellular processes including apoptosis that may affect the mutant frequency. |
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| Keywords: | p53 mutation apoptosis |
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