| 钙离子通道基因CACNA1C多态性与原发性高血压病的关系研究 |
| |
| 引用本文： | 孙倩,郑松贵,张国强,王尧杰,王淑芬,包其郁,牛宇欣,胡云良.钙离子通道基因CACNA1C多态性与原发性高血压病的关系研究[J].中国卫生检验杂志,2011(6):1319-1321. |
| |
| 作者姓名： | 孙倩 郑松贵 张国强 王尧杰 王淑芬 包其郁 牛宇欣 胡云良 |
| |
| 作者单位： | 温州医学院附属二院检验科;浙江省温州市鹿城区人民医院;中国科学院北京基因研究所;温州市鹿城区莲池社区卫生服务中心;美国佛罗里达大学; |
| |
| 基金项目： | 浙江省科技厅课题(2008C33028); 温州市鹿城区科技局课题(s070116) |
| |
| 摘 要： | 目的:探讨钙离子通道基因CACNA1C的SNP位点rs10848683C/T、rs2299661C/G与原发性高血压的关系。方法:采用多重聚合酶链反应方法及基质辅助激光解析-飞行时间质谱分析技术对413例中国汉族原发性高血压患者以及372例正常对照CACNA1C基因rs10848683C/T、rs2299661C/G的等位基因进行检测,观察各基因型频率及等位基因频率。结果:原发性高血组rs10848683 T等位基因频率与对照组相比无明显差异(58.24%:60.69%,P>0.05),OR=0.472,95%C I:0.382-1.441;原发性高血组rs2299661 G基因频率与对照组相比无明显差异(63.80%:64.83%,P>0.05),OR=1.255,95%C I:0.636~2.477。结论:CACNA1C rs10848683C/T rs2299661C/G基因多态性与中国汉族人群原发性高血压的发生不具有关联性。
|
| 关 键 词： | 原发性高血压 钙离子通道a1c亚基 基因多态性 |
The relationship between CACNA1C polymorphism and essential hypertension |
| |
| SUN Qian,ZHENG Song-Gui,ZHANG Guo-Qiang,WANG Yao-Jie,WANG Shu-Fen,BAO Qi-Yu,NIU Yu-xin,HU Yun-liang.The relationship between CACNA1C polymorphism and essential hypertension[J].Chinses Journal of Health Laboratory Technology,2011(6):1319-1321. |
| |
| Authors: | SUN Qian ZHENG Song-Gui ZHANG Guo-Qiang WANG Yao-Jie WANG Shu-Fen BAO Qi-Yu NIU Yu-xin HU Yun-liang |
| |
| Institution: | SUN Qian1,ZHENG Song-Gui2,ZHANG Guo-Qiang3,WANG Yao-Jie2,WANG Shu-Fen4,BAO Qi-Yu1,NIU Yu-xin5,HU Yun-liang1 |
| |
| Abstract: | Objective:To explore the association between CACNA1C SNP(rs10848683C/T rs2299661C/G) and essential hypertension.Methods: For 413 Han nationality hypertensives and 372 normal control,Multi-polymerase chain reaction and matrix assisted laser desorption ionization time of flight mass spectrometry were performed to detect the genotype and allele frequency of the 2 SNP sites in CACNA1C.Results: The T allele frequency of rs10848683 in essential hypertensive group was not significantly different from that in norma... |
| |
| Keywords: | Essential hypertension A1c subunits of calcium channel Polymorphism |
| 本文献已被 CNKI 等数据库收录！ |
|
