武汉市前列腺癌的流行病学研究

前列腺癌是欧美国家男性的主要死亡原因，我国还没有全面的发病率和死亡统计资料。为了解我国前列腺癌的流行情况，在武汉市１９９０～１９９２年前列腺癌的发病及死亡报告的基础上，收集了１９９０～１９９５年住院治疗的１０２例前列腺癌现患病例进行了１１配比的病例对照研究。结果显示：武汉市前列腺癌的发病率和死亡率分别为１．３７／１０万和０．７５／１０万，世界人口年平均标化发病率和死亡率分别为１．１０／１０万和０．６６／１０万。泌尿系统病史〔ＯＲ＝５．４２，９５％可信区间（ＣＩ）＝１．５６～１８．８３〕、子女数超过３个（ＯＲ＝２．４３，９５％ＣＩ＝１．１７～５．０２）、青壮年期每周性交超过３次（ＯＲ＝３．３８，９５％ＣＩ＝１．５１～７．５８）、滥用药物（ＯＲ＝４．１１，９５％ＣＩ＝１．６５～１０．２５）、体质指数高（ＯＲ＝２．５８，９５％ＣＩ＝１．３０～５．１１）等是前列腺癌的危险因素，而体力劳动（ＯＲ＝０．３５，９５％ＣＩ＝０．１７～０．７１）、初次遗精年龄晚于１８岁（ＯＲ＝０．２０，９５％ＣＩ＝０．０８～０．５２）等是其保护性因素。

Epidemiological Study on Human Prostate Cancer in Wuhan City

In America, Canada and many European countries, prostate cancer is the most common cancer and the second leading cause of cancer death in men. In China, the morbidity rate and mortality rate of prostate cancer are unknown. Based on the reports of Wuhan cancer surveillance in 1990-1992, this study researched the epidemiological characterics of prostate cancer. The results showed that morbidity rate and mortality rate in Wuhan city are 1.37 and 0.75 per 100,000 respectively, and the standardized morbidity rate and standardized mortality rate are 1.10 and 0.66 per 100,000 respectively. They also showed that history of urinary diseases (OR = 5.42, 95% confidence interval (CI): 1.56-18.83), children number with more than 3 (OR = 2.43, 95% CI: 1.17-5.02), coitus with more than 3 times per week in youth (OR = 3.38, 95% CI: 1.51-7.58), frequent use of sexual drugs (OR = 4.12, 95% CI: 1.65-10.25) and high body mass index (OR = 2.58; 95% CI: 1.30-5.11) are identified as risk factors of prostate cancer statistically, but physical labor (OR = 0.35, 95% CI: 0.17-0.71) and age of first nocturnal emission after 18 years old (OR = 0.20, 95% CI: 0.08-0.52) are protective factors.