深海鱼油改善小鼠记忆功能的实验研究

目的通过小鼠实验探讨深海鱼油改善记忆功能的作用。方法 120只雄性SPF级昆明种小鼠随机分为溶剂对照组及深海鱼油低、中、高4个剂量组。每日分别灌胃给予0、0.15、0.30和0.60g/kg BW的深海鱼油,连续30天。于末次给药后次日进行跳台试验、避暗试验和水迷宫试验,并记录相应的指标。结果深海鱼油中剂量组小鼠的跳台试验潜伏期延长,深海鱼油中剂量组小鼠的水迷宫试验到达终点的时间缩短(P<0.05)。避暗试验中,各剂量组与对照组之间的各项指标的差别均无统计学意义(P>0.05)。结论深海鱼油具有辅助改善小鼠记忆的功能。

Effect of deep-sea fish oil on improving memory in mice

Objective To investigate the effects of deep-sea fish oil on improving memory in mice.Methods One hundred and twenty male Kunming mice were allocated randomly into four groups:the control group and low-,medium-and high-dose group,and each group was administrated daily with deep-sea fish oil of 0,0.15,0.30 and 0.60g/kg BW respectively per day for 30 days.The effects of deep-sea fish oil on memory were investigated by step-down test,step-through test and water maze tests.Results In the medium-dose group,the latency phase was prolonged in the step-down test,and the time reached to the final point in the water maze test was shorter(P<0.05).The indicators of passive avoidance test were not different statistically between fish oil groups and control group(P>0.05).Conclusion Deep-sea fish oil may play an important role in memory improvement in mice.