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谷胱甘肽硫转移酶基因GSTM1及GSTT1缺失与肺癌发病关系的研究
引用本文:蓝青,何兴舟,Debra Costa,田琳玮,陆旭邦,Judy Mumford.谷胱甘肽硫转移酶基因GSTM1及GSTT1缺失与肺癌发病关系的研究[J].卫生研究,1999,28(1):9-11.
作者姓名:蓝青  何兴舟  Debra Costa  田琳玮  陆旭邦  Judy Mumford
作者单位:1. 中国预防医学科学院环境卫生与卫生工程研究所,北京,100050
2. 美国北卡罗莱纳大学公共卫生学院
3. 云南省宣威市人民医院
4. 美国环保局健康影响研究会
摘    要:在我国肺癌高发区云南省宣威市进行了一次1:1配对的以人群为基础的病例对照研究,共收集86例新发肺癌病人,并选择86例与病例相同性别、相同燃料品种,年龄相差2岁以内的宣威居民作为对照。

关 键 词:肺癌  基因多态性  GSTM1  GSTT1  基因缺失

Glutathione S-transferase GSTM1 and GSTT1 genotypes and susceptibility to lung cancer
Debra Costa,Judy Mumford.Glutathione S-transferase GSTM1 and GSTT1 genotypes and susceptibility to lung cancer[J].Journal of Hygiene Research,1999,28(1):9-11.
Authors:Debra Costa  Judy Mumford
Institution:Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Abstract:A 1:1 matched population-based case-control study was conducted in Xuanwei City, Yunnan Province, where the lung cancer mortality is among China's highest. In this study there were 86 newly diagnosed lung cancer cases and 86 matched control subjects with the same sex, fuel type used, and age(+/- 2 years). Buccal cells were collected from each subject to determine the genotypes of GSTM1 and GSTT1. It was found that the rate of GSTM1 null genotype was higher in the case group than in the control group, and its odds ratio was 2.39(95% CI: 1.25-4.56). The odds ratio became 2.62(95% CI: 1.33-5.15) when other possible confounding factors such as smoking, COPD, and the lifetime exposure to unvented fuel combustion (tons) were adjusted. No association was found between GSTT1 null genotype and lung cancer. The rate of GSTM1 null genotype in Xuanwei City was found to be similar to those of other Chinese populations.
Keywords:lung cancer  gene polymorphism  case  control study  
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