电解铝工人机体铝、氟负荷及脂质过氧化水平研究

为研究铝氟联合暴露的电解铝工人脂质过氧化水平与抗氧化酶活性的改变，寻找其早期生物监测指标，选取电解铝工人65人和对照工人52人，测定血清和尿中铝，氟浓度，测定血清中谷胱甘肽过氧化物酶（GSH－Px)活性，丙二醛（MDA）浓度及全血超氧化物歧化酶（SOD）活性，测定血清中铅，锌浓度，骨骼摄片，结果显示：与对照组比较，暴露组血清和尿中铝，氟浓度均增高，GSH－Px活性降低，MDA浓度增高，SOD活性增高，铜浓度升高，锌浓度降低（均P＜0．001），血清铝，氟浓度皆与GSH－Px活性呈负相关，且均与MDA浓度，SOD活性呈正相关，提示：血清铝，氟浓度可以较清晰地反映机体铝，氟负荷情况，骨相改变之前，铝氟联合暴露工人脂质过氧化水平升高，微量元素铜代谢异常，血清MDA浓度和GSH－Px活性有望成为其健康监护的早期生物监测指标；SOD活性升高可能是机体的代偿作用。

Study on lipid peroxidation of electrolyzing-aluminum workers

In order to study the changes in lipid peroxidation level and anti oxidase activity in electrolyzing aluminum workers exposed to both aluminum and fluoride and to find out the sensitive biological monitoring indicators, 65 electrolyzing aluminum workers are recruited as exposed group and 52 healthy workers as control group. Serum and urine aluminum and fluoride concentration, serum glutathione peroxidase(GSH Px) activity, serum malonyl dialdehyde (MDA) concentration, whole blood superoxide dismutase(SOD) activity, serum cuprum and zinc concentration, and X ray of skeleton are detected and taken. The results showed that aluminum and fluoride concentration in serum and urine increase, GSH Px activity reduces, MDA concentration increases and SOD activity increases, cuprum concentration increases and zinc concentration reduces significantly ( P <0 001) in exposed group compared with those of control group. Both serum aluminum and fluoride concentration are correlated inversely with GSH Px activity, and correlated with MDA concentration and SOD activity. It is suggested that serum aluminum and fluoride concentration can clearly reflect the loading capacity of body aluminum and fluoride. Occupational exposure to both aluminum and fluoride lead to rising of lipid peroxidation and abnormal metabolism of cuprum and zinc before changes in skeleton occurred. Serum MDA concentration and GSH Px activity might be the potential early stage indicators of biological surveillance for electrolyzing aluminum workers' health. The increase of SOD activity may be a kind of body compensations.