| 铬化合物对健康影响的研究进展 |
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| 引用本文： | 史黎薇.铬化合物对健康影响的研究进展[J].卫生研究,2003,32(4):410-412. |
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| 作者姓名： | 史黎薇 |
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| 作者单位： | 中国疾病预防控制中心环境与健康相关产品安全所,北京,100021 |
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| 基金项目： | AustraliaResearchCounciltheUniversityofSydneyCancerResearchFund |
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| 摘 要： | 综述了铬化合物 (Cr)在自然界的存在形式 ,工业用途及其对健康的影响 ,尤其是讨论了铬中间产物Cr(V IV)的形成及其毒性 ,以及它们对DNA损伤的机理 ,进而得出结论 :铬中间产物是造成DNA损伤的主要化合物 ,但活性自由基的作用也不可忽视
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| 关 键 词： | 铬中间产物 DNA损伤 健康影响 |
| 文章编号： | 1000-8020(2003)04-0410-03 |
| 修稿时间： | 2002年12月2日 |
Studies on the effects of chromium complexes |
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| Shi Liwei Institute for Environmental Hygiene and Health Related Product Safety,Chinese Center for Disease Control,Beijing ,China.Studies on the effects of chromium complexes[J].Journal of Hygiene Research,2003,32(4):410-412. |
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| Authors: | Shi Liwei Institute for Environmental Hygiene and Health Related Product Safety Chinese Center for Disease Control Beijing China |
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| Institution: | Shi Liwei Institute for Environmental Hygiene and Health Related Product Safety,Chinese Center for Disease Control,Beijing 100021,China |
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| Abstract: | The existence of chromium complexes in nature, their industrial uses, and their health impacts were reviewed in this paper. The toxic and the formation of Cr(V/IV) complexes and the mechanisms of DNA damage were discussed in particular. The major damaging specises responsible for the genotoxicity were Cr(V) or Cr(IV) complexes. However, the function of reactive organic intermediates could not be excluded. |
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| Keywords: | chromiun intermediants DNA damage health impact |
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