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天津市区中老年人血清同型半胱氨酸水平与认知功能调查
引用本文:孔海燕,蒋与刚,黄承钰,房恒通,刘静,孙畅,房红芸,庞伟.天津市区中老年人血清同型半胱氨酸水平与认知功能调查[J].卫生研究,2008,37(6).
作者姓名:孔海燕  蒋与刚  黄承钰  房恒通  刘静  孙畅  房红芸  庞伟
作者单位:1. 四川大学华西公共卫生学院营养与食品卫生学教研室,成都,610041
2. 军事医学科学院卫生学环境医学研究所
基金项目:达能营养中心"膳食营养研究与宣教基金"资助项目
摘    要:目的调查天津市区中老年人血清同型半胱氨酸水平及认知功能状况,为下一步营养干预提供科学依据。方法根据知情同意的原则,随机选取天津市区55~94岁中老年人为研究对象,运用简易精神状态量表(MMSE)测定认知功能,筛查认知损害者;抽空腹静脉血,酶转换法测定血清总同型半胱氨酸(tHcy)含量。采用SPSS软件对认知功能的影响因素进行多元线性回归分析。结果天津市区中老年人血清tHcy含量均值为(15.95±7.29)μmol/L,高同型半胱氨酸血症(hyperhomocysteinemia,HHE)发生率45.4%,男性HHE均值及发生率高于女性(P<0.001);MMSE评分均值(26.74±2.71)分,认知损害(CI)发生率为26.0%,男、女之间MMSE评分均值与CI发生率均无显著差异。认知水平随受教育程度提高而提高、随年龄增加而降低。结论天津市区老年人群中高同型半胱氨酸血症和认知损害发生率高,值得关注。

关 键 词:高同型半胱氨酸血症  中老年人  认知损害

A survey on serum homocysteine levels and cognitive function of the middle-aged and elderly persons in Tianjin City
KONG Haiyan,JIANG Yugang,HUANG Chengyu,FANG Hengtong,et al..A survey on serum homocysteine levels and cognitive function of the middle-aged and elderly persons in Tianjin City[J].Journal of Hygiene Research,2008,37(6).
Authors:KONG Haiyan  JIANG Yugang  HUANG Chengyu  FANG Hengtong  
Institution:KONG Haiyan,JIANG Yugang,HUANG Chengyu,FANG Hengtong,et al.West China School of Public Health,Sichuan University,Chengdu 610041,China
Abstract:Objective To explore the serum homocysteine levels and cognitive function status of the middle-aged and elderly persons in Tianjin city in order to provide fundamental data for the nutritional intervention trial.Methods The subjects between the ages of 55 and 94 years were randomly recruited in the study.The cognitive function of the subjects were evaluated by the Mini Mental State Examination(MMSE),and then screened the subjects with cognitive impairment(CI).Total homocysteine(tHcy) levels in fasting serum were measured by enzyme transition method,the correlation between tHcy levels and the cognitive function were statistically analyzed.Results The mean of serum tHcy levels were(15.95±7.29)μmol/L,the prevalence of hyperhomocysteinemia(HHE) was 45.4%,and man had a higher rates than woman(P<0.001);the mean MMSE scores were(26.74±2.71)points,the prevalence of CI was 26.0%,and there were no significant differences between man and woman in CI prevalence.Cognitive function status was positively correlated with education and negatively correlated with age.Conclusion It was remarkable that higher prevalence of HHE and CI existed in the middle-aged and elderly persons.
Keywords:hyperhomocysteinemia  the middle-aged and elderly person  cognitive impairment
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