腹腔镜全子宫切除术对血清IL-2、IL-10的影响

目的:研究腹腔镜全子宫切除术(laparoscopy total hysterectomy,LTH)对机体免疫功能的影响程度。方法:选择因良性疾病需行LTH术的患者32例作为研究对象(LTH组);对照组为同期行开腹子宫切除术(abdominal total hysterectomy,ATH)且条件相似的28例患者(ATH组)。测定两组术前1天和术后1、4天血清IL-2、IL-10表达水平。结果:①两组术后1天外周血IL-2水平显著低于术前(均P<0.05),但ATH组下降程度明显大于LTH组(P<0.05);ATH组术后4天外周血IL-2水平较术后1天有所升高,但仍显著低于术前(P<0.05),LTH组术后4天IL-2回升至术前水平(P>0.05),与ATH组相比差异有统计学意义(P<0.05)。②ATH组术后1天外周血IL-10含量显著高于术前(P<0.05),术后4天有所下降,但仍明显高于术前(P<0.05);LTH组术后1、4天外周血IL-10较术前有所升高,但差异无统计学意义(P>0.05),与ATH组相比差异有统计学意义(P<0.05)。结论:LTH与ATH相比,创伤轻,对机体免疫功能影响小。

The effect of Laparocopy total hysterectomy on IL-2, IL-10

Objective:To study the effect of laparoscopy total hysterectomy(LTH) on immune function. Methods:32 women who suffered from benign diseases and had hysterectomy signs were chosen underwent laparoscopy total hysterectomy(LTH group),28 patients were underwent abdominal total hysterectomy who had matched conditions were chosen at the same time(ATH group).Interleukin 2(IL-2) and Interleukin 10(IL-10)at 1 day before and 1,4 days after operation were measured. Results:① The level of IL-2 decreased markedly on day 1 after operation in both LH and AH groups(P<0.05),but significantly lower in the latter(P<0.05).On day 4,the level of IL-2 increased slightly in AH group,but still significantly lower than preoperative values(P<0.05),whereas it increased to the preoperative values in LH group(P>0.05),there was marked difference between two groups(P<0.05).② The level of IL-10 increased significantly in ATH group(P<0.05) but not in LTH group(P>0.05)on 1,4 days after operation.There was significant difference between two groups(P<0.05). Conclusion:LTH can cause less tissue injury,so it does not significantly affect immune function compared with ATH.