妊娠高血压综合征患者胎儿生长发育与白细胞介素-6的关系

目的:了解妊高征患者胎儿生长发育与白细胞介素-6(IL-6)水平的关系。方法:对2002年9月2004年9月50例妊娠高血压综合征患者(妊高征组)及30例正常孕妇(对照组)胎儿生长情况进行评价。采用酶联免疫吸附试验(ELISA法)检测两组母血清及羊水中IL-6的含量。结果:①中、重度妊高征患者低体重儿发生率显著高于正常妊娠组(P<0.01);②妊高征组母血清IL-6含量随病情加重呈升高趋势,中、重度妊高征组母血清IL-6含量显著高于正常妊娠组(P<0.01),羊水IL-6含量随妊高征病情加重呈下降趋势,中、重度妊高征组羊水IL-6含量显著低于正常妊娠组(P<0.01),母血清IL-6与羊水IL-6无显著相关关系(r=-0.21,r=-0.29,P>0.05);③妊高征组中24例新生儿出生体重低于2 500 g,其羊水IL-6含量显著低于新生儿出生体重达到2 500 g以上者,羊水IL-6水平与新生儿体重在妊高征组未发现明显相关性(r=0.232,P>0.05)。结论:妊高征患者的免疫活性细胞释放过多的IL-6,参与了妊高征的免疫损伤过程;妊高征患者胎盘产生并转运IL-6至羊水的能力下降,致羊水IL-6含量下降,对妊高征发病及其胎儿生长发育可能有重要影响。

The relation between human fetal growth and detection of interleukin -6 (IL -6 )in pregnancy induced hypertension

Objective:To study the relation between human fetal growth and levels of interleukin-6 in pregnancy induced hypertension(PIH).Methods:50 patients with PIH(PIH group) and 30 healthy pregnant women in their late trimester(control group) were studied from Sep.2002 to Sep.2004.The human fetal growth of them was studied after delivery.Enzymenked immunosorbent ssay(ELISA) was used to detect IL-6 level of maternal serum and amniotic fluid.Results:(1)There was statistically significant difference in the cases whose newborn's weights were lower than 2.5kg between the moderate and severe PIH group and the control group(P<0.01).(2)The level of IL-6 in maternal serum had a increasing trend as PIH degree.In moderate and severe PIH,IL-6 levels in maternal serum were significantly higher than that of normal pregnancy(P<0.01);The IL-6 levels of amniotic fluid had a decreasing trend as PIH degree.In moderate and severe PIH,IL-6 levels in amniotic fluid were significantly lower than that in normal pregnancy(P<0.01);IL-6 in maternal serum had no high correlation to IL-6 in amnitoic fluid.(3) In PIH group,the IL-6 levels of amniotic fluid in the 24 cases who had low newborn's weight were lower than that of the cases whose newborn's weights were higher than 2.5kg;but in PIH group,the IL-6 level in amniotic fluid was not related to the weight of the newborn.Conclusion:In PIH,the immune activity is rising,the IL-6 is overproduced by activated immune cells and it may involve in immune respond of organism and damage of vasicular endothelium;Decrease of IL-6 in amniotic fluid shown that the capability of production and transport of IL-6 decline in placenta of PIH patient,and these result in ischemia of placenta trophoblast and disturbance of the growth and development of placenta and fetus.