特发性胎儿生长受限患者胎盘组织中XIAP和Bax的意义

目的:探讨特发性胎儿生长受限(IFGR)胎盘组织中XIAP、Bax的表达及意义。方法:选取我院2010年7月～2011年4月剖宫产分娩的IFGR孕妇30例作为实验组,同期因社会因素剖宫产分娩的正常足月孕妇30例作为对照组。用免疫组化法检测胎盘组织XIAP、Bax的表达水平。结果:①XIAP在胎盘合体滋养细胞中的表达,实验组(114.562±5.167)低于对照组(144.430±7.311),差异有统计学意义(P<0.05)。②Bax在胎盘合体滋养细胞中的表达,实验组(146.513±10.611)高于对照组(113.673±9.631),差异有统计学意义(P<0.05);③实验组胎盘组织中XIAP与Bax的表达呈负相关(r=-0.761,P<0.05);对照组胎盘组织中XIAP与Bax的表达无相关性(r=0.034,P>0.05)。结论:胎盘组织中XIAP表达降低、Bax表达增加促使了胎盘滋养细胞的过度凋亡,可能是IFGR发病机制中的重要环节之一。

Significances of XIAP and Bax in placental tissue of patients with idiopathic fetal growth restriction

Objective:To explore the expressions and significances of XIAP and Bax in placental tissue of patients with idiopathic fetal growth restriction(IFGR).Methods:Thirty pregnant women with IFGR who gave birth to their babies in the hospital via cesarean section from July 2010 to April 2011 were selected as experimental group,while thirty full-term pregnant women who gave birth to their babies in the hospital via cesarean section because of social factor during the same period were selected as control group.Immunohistochemical method was used to detect the expression levels of XIAP and Bax in placental tissue.Results:The expression level of XIAP in placental syncytiotrophoblast cells of experimental group was(114.562±5.167),which was significantly lower than that of control group(144.430±7.311)(P<0.05).The expression level of Bax in placental syncytiotrophoblast cells of experimental group was(146.513±10.611),which was significantly higher than that of control group(113.673±9.631)(P<0.05).There was a negative correlation between XIAP expression and Bax expression in placental tissue of experimental group(γ=-0.761,P<0.05);while there was no correlation between XIAP expression and Bax expression in placental tissue of control group(γ=0.034,P>0.05).Conclusion:Down-regulation of XIAP and up-regulation of Bax in placental tissue can promote excessive apoptosis of placental syncytiotrophoblast cells,which may be one of the important pathogenesis of IFGR.