NF-κB在子痫前期中的表达及意义

目的:探讨NF-κB在子痫前期胎盘中的表达及意义。方法:选取2008年1月～2010年1月在海南省人民医院住院患者90例,其中对照组30例,子痫前期患者60例(轻度30例,重度30例)。采用免疫组化法检测胎盘NF-κB p65、IκB-α的表达。结果:①对照组与子痫前期患者的胎盘NF-κB p65和IκB-α表达比较,子痫前期组较对照组的胎盘NF-κBp65表达明显升高,IκB-α表达明显降低(P<0.01)。②轻度与重度子痫前期患者胎盘NF-κBp65和IκB-α表达变化,子痫前期组重度组较子痫前期轻度组胎盘NF-κB p65表达明显升高,IκB-α表达明显降低(P<0.01)。结论:子痫前期患者胎盘NF-κB活化增强,参与免疫炎症反应及胎盘细胞损伤,从而参与子痫前期的发病过程。

Expression and significance of NF-κB in preeclampsia

Objective:To explore the expression and significance of NF-κB in placenta of patients with preeclampsia. Methods:90 hospitalized patients were selected from the hospital from January 2008 to January 2010,including 30 patients in control group and 60 patients in preeclampsia group(30 patients with mild preeclampsia and 30 patients with severe preeclampsia).Radioimmunoassay was used to detect the expressions of NF-κB p65 and IκB-α in placenta. Results:The expression level of NF-κB p65 in placenta in preeclampsia group was significantly higher than that in control group,while the expression level of IκB-α in placenta in preeclampsia group was significantly lower than that in control group(P<0.01).The expression level of NF-κB p65 in placenta in severe preeclampsia group was significantly higher than that in mild preeclampsia group,while the expression level of IκB-α in severe preeclampsia group was significantly lower than that in mild preeclampsia group(P<0.01). Conclusion:NF-κB in placenta of patients with preeclampsia is activated and enhanced,and it participates in immune inflammatory response and injury of placental cells,thus,it participates in the pathogenesis of preeclampsia.