血管细胞粘附分子-1与妊娠期高血压疾病的相关性

目的:探讨血管细胞粘附分子-1(VCAM-1)在妊娠期高血压疾病中的病理生理作用及二者的相关性。方法:用酶联免疫吸附法(ELISA)对29例妊娠期高血压疾病患者(分妊娠期高血压组7例,子痫前期组22例),15例正常妊娠孕妇(正常孕妇组),分3个孕期即16～21周、25～28周、33～42周,14例非孕健康育龄妇女(正常对照组),所有对象均抽取清晨空腹肘静脉血测定血浆VCAM-1值。结果:子痫前期组VCAM-1值(1471.95±423.12)ng/ml与妊娠期高血压组VCAM-1值(880.49±256.63)ng/ml相比明显升高,有显著性差异(P(0.01),妊娠期高血压组的VCAM-1值与正常孕晚期组(936.31±217.53)ng/ml相比,无显著性差异(P>0.05),正常孕晚期组VCAM-1值与正常对照组(614.91±412.99)ng/ml比较,有显著性差异(P(0.02),正常孕妇组不同孕龄的VCAM-1值比较,无显著性差异(P>0.05)。结论:外周血中VCAM-1水平变化与妊娠期高血压疾病密切相关,随着病情加重VCAM-1值明显升高,VCAM-1对预测子痫前期的发生、发展及终止妊娠时机的选择有重要作用;VCAM-1值在正常妊娠中不随孕龄的增长而升高。

Study of the relationship between vascular cell adhesion molecule-1 and hypertensive disorder complicating pregnancy.

Objective:To discuss the role of pathogenesis of vascular cell adhesion molecule-1(VCAM-1) in patients with hypertensive disorder complicating pregnancy,and to discuss the relationship between VCAM-1 and hypertensive disorder complicating pregnancy.Methods:The fasting plasma of VCAM-1 were measured by ELISA in 29 patients with hypertensive disorder complicating pregnancy(7 cases with gestational hypertention,22 cases with pre-eclampsia),15 healthy pregnant women at 16 to 21weeks' gestation and 25 to 28 weeks' gestation and 33 to 42 weeks' gestation,respetively(normal pregnancy group),14 nomal healthy no pregnant women(normal control group).Results:The plasma levels of VCAM-1 in patients with pre-eclampsia group(1471.95±423.12)ng/ml were significantly higher than those in patients with gestational hypertention group(880.49±256.63)ng/ml(P﹤0.01).There was not significantly different between the plasma levels of VCAM-1 in patients with gestational hypertention group and those in normal later-pregnant women group(936.31±217.53)ng/ml(P>0.05).The levels of plasma VCAM-1 in healthy later-pregnant women were significantly increased than those in normal control group(614.91±412.99)ng/ml(P<0.02).The levels of plasma VCAM-1 were no significantly different in normal pregnant group at different trimester(P>0.05).Conclusion:The levels of plasma VCAM-1 increase with the severity of patients with hypertensive disorder complicating pregnancy.The levels of plasma VCAM-1 specially play a important role to predict the severity of patients with pre-eclampsia.It is important to predict the change of their levels for termination of labour.The levels of plasma VCAM-1 are not increased with pregnant progress.