妊娠期疾病类型与甲状腺功能异常相关性分析

目的研究妊娠期疾病类型与甲状腺功能异常相关性。方法回顾性分析2015年1月-2017年1月期间在天津港口医院治疗的107例孕妇,根据妊娠期是否患病分为A组、B组与对照组。A组为22例确诊为妊娠期糖尿病的患者;B组为36例确诊为妊娠期高血压疾病的患者;对照组为49例妊娠期血糖与血压正常、无其他疾病的孕妇。所有研究对象妊娠期定期抽取静脉血检测甲状腺功能、血压及血糖水平。采用妊娠期高血压疾病诊断标准、妊娠期糖尿病诊断标准以及妊娠期甲状腺疾病诊断标准联合评价。结果此研究发现糖尿病组与对照组在孕中期游离T4值、A组与对照组在孕晚期、B组与对照组在孕中期和孕晚期的促甲状腺激素(TSH)值对比,差异均有统计学意义(均P<0.05);3组孕妇不同妊娠时期临床甲状腺功能亢进、减退的发病情况各组别数据对比,差异无统计学意义(P>0.05);A组、B组与对照组在孕中期与孕晚期亚临床甲状腺功能减退发病情况数据对比,A组、B组与对照组在不同妊娠时期低T4血症发病情况数据对比,差异均有统计学意义(均P<0.05);孕早期仅甲状腺过氧化物酶抗体(TPOAb)阳性与甲状腺正常数据对比,B组发生率高于对照组、A组发生率低于对照组,差异均有统计学意义(均P<0.05)。结论与正常孕妇相比,妊娠期高血压疾病与妊娠期糖尿病患者在不同妊娠期的游离T4水平更低、TSH水平更高,且随着妊娠期的增长,变化趋势不断增大;妊娠期疾病类型与甲状腺功能异常存在着联系,妊娠期高血压疾病和糖尿病患者甲状腺功能异常发病率明显更高。

Analysis of the relationship between the type of pregnancy and thyroid dysfunction

Objective To study the relationship between the type of pregnancy and thyroid dysfunction.Methods A retrospective selection of 107 cases of pregnant women treated in Tianjin port hospital from January 2015 to January 2017 was divided into group A,group B and control group according to whether the disease was during pregnancy.A group of 22 patients diagnosed with gestational diabetes mellitus;B group of 36 patients diagnosed with hypertensive disorders of pregnancy;the control group was 49 cases of gestational blood glucose and normal blood pressure,no other disease pregnant women.All subjects underwent periodic withdrawal of venous blood during pregnancy to detect thyroid function,blood pressure,and blood glucose levels.The diagnostic criteria of diagnostic criteria for pregnancy hypertension,gestational diabetes mellitus,diagnostic criteria for thyroid disease during pregnancy were evaluated.Results The T4 values of diabetes mellitus and control group in the second trimester were significantly higher than those in the control group(P<0.05).There was significant difference between the diabetic group and the control group in the third trimester,the hypertensive group and the control group in the second trimester and the third trimester(P<0.05).There was no significant difference in the incidence of clinical hyperthyroidism and hypothyroidism between the three groups(P>0.05).The diabetic group,the hypertensive group and the control group were significantly higher than those in the control group The incidence of hypothyroidism,diabetes mellitus and control group in the different pregnancy period of low T4 blood disease incidence data were significantly different,were statistically significant(P<0.05);early pregnancy only TPOAb positive and thyroid normal data,the incidence of hypertension group was higher than that of the control group.The incidence of diabetes mellitus was lower than that of the control group,the difference was significant(P<0.05).Conclusion Compared with normal pregnant women,gestational hypertension and gestational diabetes mellitus have lower levels of free T4 in different gestational periods and higher TSH levels,and with increasing gestation,the trend is increasing;gestational disease Type and thyroid function abnormalities exist in pregnancy hypertensive and diabetic patients with abnormal incidence of thyroid dysfunction was significantly higher.