乳腺浸润性导管癌钼靶X线表现与ER、PR及C-erbB-2表达的相关性研究

目的:通过分析乳腺浸润性导管癌的X线表现,预测乳腺浸润性导管癌的雌激素受体(ER,estrogen receptor)、孕激素受体(PR,progesterone receptor)、人类上皮生长因子受体-2(C-erbB-2,human epithelium growth receptor 2)的表达。方法:选择30例资料完整的乳腺浸润性导管癌患者,术后对标本进行免疫组织化学染色并判断这些免疫因子的表达情况;将X线表现中的肿块伴有的恶性钙化、肿块边缘的毛刺和有无合并乳腺腺体增生症与ER、PR及C-erbB-2表达情况进行对比分析。结果:毛刺组的ER阳性率较无毛刺组高(P<0.05);伴有腺体增生症组ER阳性率较无腺体增生症者高(P<0.05);钙化组的C-erbB-2阳性率较无钙化组高(P<0.05)结论:通过对乳腺癌钼靶X线征像的分析可以反映ER、PR及C-erbB-2的表达情况,指导临床治疗和效果评价。

Investigation on correlation between molybdenum target X-ray manifestations and estrogen receptor, progesterone receptor and C-erbB-2 expression of patients with invasive ductal carcinoma

Objective:To predict the expression levels of estrogen receptor(ER),progesterone receptor(PR) and human epithelium growth receptor-2(C-erbB-2) by analyzing the molybdenum target X-ray manifestations of invasive ductal carcinoma.Methods: 30 patients with invasive ductal carcinoma were selected,and the expression levels of immune factors were detected by immunohistochemistry; X-ray manifestations of lumps with malignant calcification,specula and complicated with mammary hyperplasia or not were compared with expression levels of ER,PR and C-erbB-2.Results:The positive rate of ER in specula group was higher than that in non-specula group(P<0.05).The positive rate of ER in lesions with mammary hyperplasia was higher than that in lesions without mammary hyperplasia (P<0.05).The positive rate of C-erbB-2 in calcification group was higher than that in non-calcification(P<0.05).Conclusion: The analysis of molybdenum target X-ray manifestations of invasive ductal carcinoma can reflect the expression levels of ER,PR and CerbB -2,which may direct clinical treatment and efficacy evaluation.