| 广州市男性吸烟对其肺功能及体内多环芳烃代谢物的影响 |
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| 引用本文： | 刘涛,朱炳辉,许瑛华,张建鹏,张伟坚,杨春,肖建鹏,罗圆,何志辉,曾韦霖,胡梦珏,林华亮,杨杏芬,张永慧,马文军.广州市男性吸烟对其肺功能及体内多环芳烃代谢物的影响[J].广东卫生防疫,2014(4):338-342. |
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| 作者姓名： | 刘涛 朱炳辉 许瑛华 张建鹏 张伟坚 杨春 肖建鹏 罗圆 何志辉 曾韦霖 胡梦珏 林华亮 杨杏芬 张永慧 马文军 |
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| 作者单位： | [1]广东省疾病预防控制中心广东省公共卫生研究院,广东广州511430 [2]环境与健康广东省“十二五”医学重点学科 ,广东广州511430 [3]广东省疾病预防控制中心 ,广东广州511430 [4]增城市疾病预防控制中心 ,广东广州511430 [5]广州市黄埔区疾病预防控制中心,广东广州511430 |
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| 基金项目： | 广东省医学科研基金项目（C2012030） |
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| 摘 要： | 目的了解广州市男性居民吸烟对其肺功能以及体内多环芳烃代谢物水平的影响。方法2012年7月采用系统抽样方法在广州市黄埔区和增城市各抽取1个社区中45岁以上的男性常住居民作为研究对象，资料收集包括问卷调查、晨尿中10种羟基多环芳烃浓度检测和肺功能检测。采用协方差和多重线性回归分析吸烟、肺功能以厦尿液中羟基多环芳烃浓度之间的关系。结果本次研究共纳入142名研究对象，平均年龄为（61，30±9．73）岁，其中吸烟者94人（66．20％）。协方差分析控制混杂因素后发现吸烟者肺功能指标1秒率（F=6．84）、用力呼气中段流量（F=5．52）和最大通气量（F=4．54）低于不吸烟者，且尿液中1-羟基萘（F=10．21）、2-羟基萘（F：8．74）和2-＋3-羟基芴（F=4．11）浓度高于不吸烟者（P〈0．05或P〈0．01）。2-羟基菲、3-羟基菲、4-羟基菲、1-羟基芘与峰流速呈负相关（β：-6．34、-6．39、-5．44、-5．03），2-羟基萘与用力呼气中段流量呈负相关（β=-5．91），1-羟基萘、2-羟基萘与最大通气量呈负相关（β=-2．85、-3．11），均P〈0．05。结论广州地区男性居民吸烟可降低肺功能并增加多环芳烃的内暴露水平，体内多环芳烃增加与肺功能下降存在相关关系。
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| 关 键 词： | 男人 吸烟 多环芳烃 肺功能试验 |
Effects of smoking on pulmonary function and urinary concentrations of polycyclic aromatic hydrocarbon metabolites among male adults in Guangzhou |
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| Institution: | LIU Tao, ZHU Bing-hui, XU Ying-hua , ZHANG Jian-peng, ZHANG Wei-jian, YANG Chun, XIAO Jian-peng, LUO Yuan, HE Zhi-hui, ZENG Wei-lin, HU Meng-jue, LIN Hua-liang, YANG Xing-fen, ZHANG Yong-hui, MA Wen- jun( 1. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; 2. The 12th Five-year Key Medical Discipine in Guangdong Province Environment and Health; 3. Guangdong Provincial Center for Disease Control and Prevention; 4. Center for Disease Control and Prevention in Zengcheng ; 5. Center for Disease Control and Prevention in Huangpu District Guangzhou.) |
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| Abstract: | Objective To investigate the effects of smoking on pulmonary function and urinary concentrations of polycyclic aromatic hydrocarbon （PAH） metabolites among male adults in Guangzhou. Methods A systematic sampling method was employed to select male adults in Huangpu District and Zengcheng during July 2012. All subjects were aged 45 years and over, lived in the location more than half year, and interviewed with the questionnaire. Ten OH-PAHs in urine and pulmonary functions were tested. Covariance and multiple linear regression analyses were employed to test relationships between smoking, pulmonary functions and OH-PAH concentrations. Results A total of 142 male adults were recruitedwhose average age was （61.30 ±9. 73） years. Ninety four of them were smokers （66. 20% ）. The covari- ance analyses revealed that the FEV1/FVC （F = 6. 84） , FEF25-75 （F = 5.52） and MVV （F = 4. 54） were lower in smokers than those in none-smokers （P 〈 0. 05 for all）. Smokers had higher concentrations of uri- nary 1-OHNa （ F = 10. 21 ） , 2-OHNa （ F = 8. 74 ） and 2- ＋ 3-OHFlu （ F = 4. 11 ） than none-smokers （P〈0.05 orP〈0.01）. Furthermore, 2-OHPhe （β= -6.34）, 3-OHPhe （β= -6.39）, 4-OHPhe （β= -5.44）, and 1-OHP （β= -5.03） had negative relationships with PEF （P 〈0.05 for all）; 2-OHNa had negative relationship with FEF25 -75 （β = - 5.91, P 〈 0. 05 ） ; 1-OHNa （β = - 2. 85 ） and 2-OHNa （β = -3.11 ） had significantly negative relationships with MVV （P 〈0. 05 for all）. Conclusion Smoking could reduce pulmonary functions of male adults in Guangzhou and increase their internal expo- sure to PAHs. The internal increase in PAHs was related to the declined pulmonary functions. |
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| Keywords: | Male Smoking Polycyclic aromatic hydrocarbons Pulmonary function test |
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