围产因素与儿童哮喘关系研究进展

儿童哮喘发病率在世界范围内有不断升高的趋势,但相关病因仍然不清楚。近年来大量的流行病学研究证据说明遗传因素、围产儿子宫内外环境暴露与儿童哮喘发生密切相关。该文从遗传因素、母亲孕期吸烟、胎儿宫内生长环境、胚胎发育水平、胎儿的免疫状况等几个角度,对近年来有关围产因素与儿童哮喘关系的流行病学研究结果进行简要综述。

Advances in research on perinatal factors and risk of childhood asthma

The prevalence of childhood asthma is increasing worldwide and the natural history of childhood asthma remains unknown.Evidences from epidemiological studies suggestsed that genetic factors and perinatal environmental exposures in or out of uterus may be associated with development of childhood asthma. In this paper,we summarized advances in epidimiological researches on association between childhood asthma and perinatal factors,such as genetic factors,maternal smoking during pregnancy,pregnancy complications,intrauterine fetal enviornment,fetal development level,delivery patterns,fetal immunological status as well as early breastfeeding patterns.