胱抑素C在婴幼儿轮状病毒肠炎肾功能损伤的应用价值

目的探讨胱抑素C在轮状病毒(RV)肠炎患儿肾功能损伤监测中的应用价值。方法选取2012年11月至2013年3月因腹泻在我院儿科住院的患儿128例,按照粪便RV抗原检测结果分为观察组(RV阳性)88例及对照组(RV阴性)40例。两组患儿均进行肾功能相关检查并对结果进行对比分析。结果 RV肠炎患儿血清尿素氮(BUN)、肌酐(CRE)和胱抑素C(Cys C)均高于对照组,差异有统计学意义(PBUN<0.01,PCRE<0.01,PCys C<0.01);RV肠炎患儿肾功能损伤发生率高于对照组,以BUN和CRE为诊断指标,差异无统计学意义(P>0.05),以Cyc C为诊断指标,差异有统计学意义(P<0.01);RV肠炎患儿Cys C异常检出率(44.3%)高于BUN、CRE的异常检出率(13.6%)。结论 RV肠炎患儿存在肾功能损伤的情况,Cys C作为一种稳定的肾功能指标,可用于RV肠炎患儿肾功能损伤的监测中,及时发现肾功能损害,并对其进行干预和治疗。

Value of Cystatin C in Infants with Renal Injury Induced by Rotavirus Enteritis

Objective To explore the clinical value of cystatin C （Cys C） in the monitoring of renal injury of infants with rotavirus （RV） enteritis. Methods 128 infants with enteritis admitted to our hospital from November 2012 to March 2013 were selected in this study. All cases were divided into the observation group （RV positive, n = 88） and the control group （RV negative, n = 40） according to the results of RV antigen detection. The related indicators of renal injury were detected and compared between two groups. Results The levels of blood urea nitrogen （BUN）, creatinine （CRE） and cystatin C （Cys C） of observation group were significantly higher than those of control group （PBUN 〈 0.01, PCRE 〈 0.01, PCys C 〈 0.01）. The incidence of renal injury of observation group was higher than that of control group; With BUN and CRE as the diagnostic indicators, there was no statistical difference between the two groups （P 〉0.05）; With Cys C as the diagnostic indicator, there was statistical difference between the two groups （P 〈0.01）; The abnormal detection rate of Cys C was 44.3%, higher than 13.6% of BUN combined with CRE. Conclusions Rotavirus （RV） enteritis in infants usually induces renal injury. As a stable renal function, Cys C can be used in the monitoring of renal injury, so as to find out renal injury as soon as possible and take intervention and treatment.