| HBsAg阳性孕妇HBsAg、HBeAg和HBVDNA关系探讨 |
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| 引用本文： | 陆向东,孙翔,翟祥军,朱凤才,许卫国,鲍倡俊,朱叶飞,卞倩,殷晓梅,彭红,朱立国,常宝龙,刘红建,刘黎静,张秋明,刘耀珍,李杰,庄辉,汪华.HBsAg阳性孕妇HBsAg、HBeAg和HBVDNA关系探讨[J].江苏预防医学,2012(1):1-3. |
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| 作者姓名： | 陆向东 孙翔 翟祥军 朱凤才 许卫国 鲍倡俊 朱叶飞 卞倩 殷晓梅 彭红 朱立国 常宝龙 刘红建 刘黎静 张秋明 刘耀珍 李杰 庄辉 汪华 |
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| 作者单位： | [1]江苏省江阴市疾病预防控制中心,无锡214434 [2]南京医科大学公共卫生学院,南京210029 [3]江苏省疾病预防控制中心,南京210009 [4]东南大学公共卫生学院,南京210009 [5]江苏省泰兴市疾病预防控制中心,泰州225400 [6]江苏省淮安市楚州区疾病预防控制中心,淮安223200 [7]北京大学医学部,北京100000 |
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| 基金项目： | 国家科技重大专项（2008ZX10002-001）; 国家科技重大专项（2009ZX10004-904）; 无锡市第三批公共卫生拔尖人才培养计划 |
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| 摘 要： | 目的研究HBsAg阳性孕妇血清HBVDNA载量与HBsAg、HBeAg滴度之间的关系。方法入组乙肝疫苗母婴阻断效果研究队列892例未经抗病毒治疗孕妇,经雅培Architect i2000分析仪检测其血清HBsAg和HBeAg,并用雅培全自动实时荧光定量系统m2000定量检测HBVDNA水平。结果 HBeAg阳性组中,HBVDNA阳性率为95.65%;HBeAg阴性组中,HBVDNA阳性率为30.08%,差异有统计学意义(P<0.05)。不同浓度组HBeAg和HBVDNA检测结果比较,差异有统计学意义(P<0.05)。不同载量HBVDNA组,HBeAg差异有统计学意义(P<0.01),且随HBVDNA含量增加而增加,成正相关(r=0.71,P<0.01);HBsAg差异也有统计学意义(P<0.01),随HBVDNA含量增加而增加,成正相关(r=0.53,P<0.01)。结论在未经抗病毒治疗的HBsAg阳性孕妇中HBVDNA载量与HBsAg、HBeAg滴度均呈正相关,HBsAg可以较好的反映HBV复制水平。
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| 关 键 词： | HBsAg HBeAg HBVDNA HBsAg阳性孕妇 |
Study the relationship between serum HBeAg,HBsAg and HBVDNA concentration in HBsAg positive mothers |
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| LU Xiang-dong,SUN Xiang,ZHAI Xiang-jun,ZHU Feng-cai,XU Wei-guo,BAO Chang-jun,ZHU Ye-fei,BIAN Qian,YIN Xiao-mei,PENG Hong,ZHU Li-guo,CHANG Bao-long,LIU Hong-jian,LIU Li-jing,ZHANG Qiu-ming,LIU Yao-zhen,LI Jie,ZHUANG Hui,WANG Hua.Study the relationship between serum HBeAg,HBsAg and HBVDNA concentration in HBsAg positive mothers[J].Jiangsu Journal of Preventive Medicine,2012(1):1-3. |
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| Authors: | LU Xiang-dong SUN Xiang ZHAI Xiang-jun ZHU Feng-cai XU Wei-guo BAO Chang-jun ZHU Ye-fei BIAN Qian YIN Xiao-mei PENG Hong ZHU Li-guo CHANG Bao-long LIU Hong-jian LIU Li-jing ZHANG Qiu-ming LIU Yao-zhen LI Jie ZHUANG Hui WANG Hua |
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| Institution: | 1 Jiangyin Center for Disease Control and prevention,Wuxi 214434,China |
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| Abstract: | Objective To study the relationship between serum HBeAg,HBsAg and HBVDNA concentration in HBsAg positive mothers.Method Quantitative measurement of serum HBV-DNA（with m2000） and HBeAg（with Architect i2000） were performed in 892 HBsAg positive mothers.Results In the HBeAg positive samples,the positive percentage of HBVDNAw was 95.62%,and in the HBeAg negative samples,the positive percentage of HBVDNAw was 30.08%,which showed a significant difference（p〈0.05） between two groups.The concentration of HBV-DNA was also of significant difference between the two groups（p〈0.05）.In the different concentration of HBV-DNA groups,both HBeAg and HBsAg show significant difference（p〈0.05）.With the increase of HBV-DNA,the HBeAg and HBsAg were increasing.Conclusion The relationship between serum HBeAg,HBsAg and HBV-DNA concentration are the positive correlation in HBsAg positive mothers without antiviral treatment,HBsAg can act as an indictor for HBV replicative status. |
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| Keywords: | HBsAg HBeAg HBVDNA HBsAg positive mothers |
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