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| 脂联素通路多态性与汉族人群2型糖尿病遗传易感性的多因素分析 | |
| 引用本文： | 赵旭,叶青,周玲,杜文聪,陆莹,李倩,叶新华,俞晓芳,马建华,成金罗,高燕勤,曹园园.脂联素通路多态性与汉族人群2型糖尿病遗传易感性的多因素分析[J].江苏预防医学,2011,22(3):1-4. |
| 作者姓名： | 赵旭 叶青 周玲 杜文聪 陆莹 李倩 叶新华 俞晓芳 马建华 成金罗 高燕勤 曹园园 |
| 作者单位： | 1. 南京医科大学公共卫生学院,江苏,南京,210029 2. 南京医科大学附属南京市第一医院,江苏,南京,210006 3. 南京医科大学附属常州市第二人民医院,江苏,常州,213003 4. 南京医科大学第三附属医院,江苏,仪征,211400 |
| 基金项目： | 国家自然科学基金，江苏省自然科学基金 |
| 摘 要： | 目的:探讨江苏汉族人群脂联素通路基因多态性和环境的联合作用与2型糖尿病的关系.方法:采用病例对照研究,收集新诊断T2DM病例(1 105例)和健康对照(1 107例)的临床和流行病学相关资料.利用Real-time PCR联合Taqman-MGB探针方法对19个多态性位点进行基因分型.结果:显性遗传模型的单因素Logi... |
| 关 键 词： | 2型糖尿病 ADIPOQ基因 PPARγ基因 RXRα基因 Logistic回归分析 |
Multivariate analysis of the polymorphisms in adiponectin pathway and susceptibility to T2DM in Han population |
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| ZHAO Xu,YE Qing,ZHOU Ling,DU Wen-cong,LU Ying,LI Qian,YE Xin-hua,YU Xiao-fang,MA Jian-hua,CHENG Jin-luo,GAO Yan-qing,CAO Yuan-yuan.Multivariate analysis of the polymorphisms in adiponectin pathway and susceptibility to T2DM in Han population[J].Jiangsu Journal of Preventive Medicine,2011,22(3):1-4. | |
| Authors: | ZHAO Xu YE Qing ZHOU Ling DU Wen-cong LU Ying LI Qian YE Xin-hua YU Xiao-fang MA Jian-hua CHENG Jin-luo GAO Yan-qing CAO Yuan-yuan |
| Institution: | ZHAO Xu,YE Qing,ZHOU Ling,DU Wen—cong,LU Ying,LI Qian,YE Xin—hua,YU Xiao—fang,MA Jian—hua,CHENG Jin—luo,GAO Yan—qing,CAO Yuan—yuan(College of Public Health in Nanjing Medical University,Nanjing 210029,China) |
| Abstract: | Objective:To explore the relationship between the genetic variants in the adiponectin pathway jointed with the environment and type 2 diabetes risk in a Jiangsu Han population.Methods: Epidemiology questionnaires and physical examinations were performed to gain the healthy status and biochemistry markers from first-diagnosed type 2 diabetes patients(n=1 105) and controls(n=1 107).The genotypes were tested with Real-time PCR and Taqman-MGB probe assays.Results: The polymorphisms of ADIPOQrs7649121 and PPARγrs3856806 showed significant differences between type 2 diabetes cases and controls in the dominant genetic model by univariate logistic regression analysis(P<0.05).With multiple logistic regression analysis,diabetes mellitus family history,hypertension,waist,serum adiponectin level,smoking,do no drink alcohol,rs7649121,rs3856806 and rs12495941 were associated with T2DM(all P<0.05).Conclusion: The effect of the genetic variants in the adiponectin pathway jointed with the environment may play a role in the susceptibility of type 2 diabetes. |
| Keywords: | type 2 diabetes mellitus ADIPOQ gene peroxisome proliferators activated receptorγ gene retinoid X receptorα gene logistic regression analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |