| 2008年广东省手足口病实验室检测结果分析 |
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| 引用本文： | 郑焕英,刘冷,郭雪,柯昌文,肖红,李柏生,王雅静,柯碧霞,王冰姝,张欣.2008年广东省手足口病实验室检测结果分析[J].华南预防医学,2009(6). |
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| 作者姓名： | 郑焕英 刘冷 郭雪 柯昌文 肖红 李柏生 王雅静 柯碧霞 王冰姝 张欣 |
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| 作者单位： | 广东省疾病预防控制中心; |
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| 基金项目： | 广东省医学科学技术研究基金(编号:C2008012) |
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| 摘 要： | 目的对广东省2008年手足口病实验室检查结果进行分析,了解2008年广东省手足口病病原学特征,为实验室诊断手足口病提供参考。方法采集2008年4—12月广东省各地送检的292例手足口病患者的粪便、肛拭子、咽拭子、疱疹液和脑脊液等标本426份和98名手足口病病例接触者的粪便、肛拭子和咽拭子等标本98份,应用RT-PCR技术检测样本中的肠道病毒、肠道病毒71型(EV71)、柯萨奇病毒A组16型(CVA16)。结果292例手足口病患者的426份各类样本中,检测到肠道病毒阳性267份,EV71病毒特异性基因片段阳性169份,CVA16特异性基因片段阳性36份,EV71和CVA16病毒核酸同时阳性3份。292例手足口病病例中,EV71的检出率较CVA16高,分别为50.68%(148/292)和11.99%(35/292),20例手足口病死亡病例均为EV71感染病例。手足口病病例粪便样本的肠道病毒、EV71和CVA16的检测阳性率最高,分别为76.72%(178/232)、45.26%(105/232)和14.66%(34/232),且在发病9 d后仍能检测到EV71病毒。98名手足口病病例接触者的各类样本中,分别检测...
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| 关 键 词： | 手足口病 逆转录-多聚酶链反应 肠道病毒属 肠道病毒71型 柯萨奇病毒A组16型 |
Analysis of the laboratory diagnosis results of hand-foot-mouth disease in Guangdong Province,2008 |
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| ZHENG Huan-ying,LIU Leng,GUO Xue,et al..Analysis of the laboratory diagnosis results of hand-foot-mouth disease in Guangdong Province,2008[J].South China JOurnal of Preventive Medicine,2009(6). |
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| Authors: | ZHENG Huan-ying LIU Leng GUO Xue |
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| Institution: | ZHENG Huan-ying,LIU Leng,GUO Xue,et al.Center for Disease Control and Prevention of Guangdong Province,Guangzhou 510300,China |
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| Abstract: | Objective To understand the pathogen characters of hand-foot-mouth disease(HFMD) and provide reference for laboratory diagnosis of HFMD.Methods A total of 524 samples including throat swabs,Herpes fluid,anal swab,feces,and other types from 292 patients and 98 close contacts all over Guangdong Province were collected from April to December in 2008.Nucleic acids of three types of viruses of enterovirus,enter virus 71(EV71) and Coxasckievirus A16(CVA16) were detected by RT-PCR method both in original samples a... |
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