首页 | 本学科首页   官方微博 | 高级检索  
     

Navelbine治疗晚期肺癌的Ⅱ期临床研究报告
引用本文:管忠震 张湘茹. Navelbine治疗晚期肺癌的Ⅱ期临床研究报告[J]. 癌症, 1993, 12(3): 217-219,226
作者姓名:管忠震 张湘茹
作者单位:中山医科大学附属肿瘤医院内科,中山医科大学附属肿瘤医院内科,中国医学科学院肿瘤医院内科,中国医学科学院肿瘤医院内科 广州 510060,广州 510060,北京 100021,北京 100021
摘    要:1992年7月至1993年2月,用NAVELBINE治疗35例Ⅲ—Ⅳ期的非小细胞肺癌患者,所有病例均经病理组织学证实,包括鳞癌12例,腺癌18例、肺泡癌3例、腺样囊腺瘤和大细胞癌各1例。实际可评价的病人34例,其中Navelbine单药治疗16例(25mg/m~2/周×4),5例PR,有效率为31.3%。联合治疗(Navelbine+CDDP)18例,CR1例(5.6%)PR8例(44.4%),总有效率为50%。主要毒性为骨髓抑制,白细胞减少Ⅲ—Ⅳ级发生率为32.4%,其中一例高龄者白细胞严重减少,合并败血症而死亡。该研究提示,Navelbine对非小细胞肺癌的治疗价值是肯定的,主要剂量限制毒性为骨髓抑制,应在肿瘤学专家的指导下使用。

关 键 词:非小细胞肺癌 肺肿瘤 药物疗法

NAVELBINE TREATMENT OF ADVANCED NSCLC-A PILOT PHASEII STUDY IN CHINA
GUAN Zhong zhen ZHANG Li ZHANG Xiang-ru SUN Yan. NAVELBINE TREATMENT OF ADVANCED NSCLC-A PILOT PHASEII STUDY IN CHINA[J]. Chinese journal of cancer, 1993, 12(3): 217-219,226
Authors:GUAN Zhong zhen ZHANG Li ZHANG Xiang-ru SUN Yan
Abstract:I 35 Cases of advanced, stage III-IV NSCLC cases, previously untreated, were treated with NAVELBINE(NVB). All cases were histological approved, Epidermoid 12 cases, Adenocarcinoma 18 cases, aveolar cell carcinoma 3 cases and Cystadenocarcinoma 1 case, Large Cell care 1 case. 16 cases were treated with single drug weekly NAVELBI-NE 25mg/m 2 for at least 4 weeks, 5 cases (31.3%) achiveved PR. 18 cases were treated with weekly NAVELBINE for 3 weeks and DDP 80mg/m 2 single inj every 4 weeks, CR 1 case and PR 8 cases, overall response rate 50% . Myelosuppresskm was the main dose-limiting toxicity, Grade III-IV leucopenia occured in 32.4%, 1 elderly case developed severe leucopenia and died of sepsis. This study showed that NAVELBINE is effective in advanced NSCLC and should be used under dose supervision of oncologist.
Keywords:NSCLC Chemotherapy Navelbine
本文献已被 CNKI 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号