胰腺癌组织中基质金属蛋白酶-7(MMP7)的表达

目的 有研究表明基质金属蛋白酶－７（ｍａｔｒｉｘ ｍｅｔａｌｌｏｐｒｏｔｅｉｎａｓｅ，７ＭＭＰ７）与部分人肿瘤的浸润和转移有一这关系。本研究旨在探讨胰腺癌组织中ＭＭＰ７的表达及其在本病发展过程中的作用。材料与方法 用免疫组化染色方法检测了５１例胰腺癌石蜡包埋组织（其中２２例为早期病变，２９你为晚期病变）中ＭＭＰ７的表达。结果 ５１例互腺癌组织中３５例（６８．６％）显示有ＭＭＰ７表达。而且，晚期胰腺

Enhanced expression of matrix metalloproteinase 7 in pancreatic carcinoma

Objective:Matrix metalloproteinases7(MMP7)is reported to be involved in the invasion and metastasis of some human tumors.In this study ,we investigated the role of MMP7 in human panereatic careinoma(PC)progression.Materials and Methods:A total of 51 cases of PC,including 22 early lesions(clinical stage Ⅰ and Ⅱ)and 29 of advanced ones(clinical stageⅢ and Ⅳ),were tested for MMP7 expression using immunostaining assay.Results:Increased MMP7 immunoreactivity was present in 35(68.6%)cases of PC,and frequently distributed in the invasive front of the tumors.More cases expressed positive MMP7 in advanced group(23/29,79.3%)than in early group(12/22,54.5%;P<0.05).Conclusion:The increased expression of MMP7 was related to PC progression and might be considered to be useful as a marker for biological aggressiveness of this malignancy.