Quality of life in women with cervical precursor lesions and cancer:a prospective, 6-month,hospital-based study in China |
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Authors: | Zhi-Mei Zhao Xiong-Fei Pan Si-Han Lv Yao Xie Shao-Kai Zhang You-Lin Qiao Xiao-Rong Qi Chun-Xia Yang Fang-Hui Zhao |
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Institution: | Zhi-Mei Zhao(Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P. R. China);Xiong-Fei Pan(Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P. R. China);Si-Han Lv(Center for Disease Control and Prevention of Chengdu Railway Bureau, Chengdu, Sichuan 610000, P. R. China);Yao Xie(Chengdu Health Inspection, Chengdu, Sichuan 610031, P. R. China);Shao-Kai Zhang(Department of Cancer Epidemiology, Cancer Institute of Chinese Academy of Medical Sciences and Peking Union Medical Colege, Beijing 100021, P. R. China);You-Lin Qiao(Department of Cancer Epidemiology, Cancer Institute of Chinese Academy of Medical Sciences and Peking Union Medical Colege, Beijing 100021, P. R. China);Xiao-Rong Qi(Department of Gynecology and 0bstetrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China);Chun-Xia Yang(Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P. R. China);Fang-Hui Zhao(Department of Cancer Epidemiology, Cancer Institute of Chinese Academy of Medical Sciences and Peking Union Medical Colege, Beijing 100021, P. R. China); |
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Abstract: | The overal survival of patients with cervical cancer has improved due to detection at an early stage and availability of comprehensive treatments in China. As patients’ lives prolonged, it is important to understand their health-related quality of life (QoL) during and after treatment. We used the EQ-5D questionnaire to assess QoL of 194 patients with cervical lesions at Sichuan University West China Second Hospital between May 2010 and January 2011. Patients were surveyed before primary treatment and at 1, 3, and 6 months after primary treatment. Results showed a consistent decline in EQ-5D scores in the spectrum of cervical lesions at each time point after treatment (alP < 0.05). For patients with precursor lesions, there was an increasing trend along the timeline of treatment (P < 0.01). For patients with early-stage cervical cancer, EQ-5D scores declined in the first month (P = 0.01) and gradualy increased to higher levels at 6 months post-treatment than those before treatment (P < 0.01). EQ-5D scores followed a similar trend in patients with advanced cervical cancer (P = 0.04), though they did not statisticaly rebound after 6 months (0.84± 0.19 vs. 0.86± 0.11,P = 0.62). Regarding advanced cervical cancer, EQ-5D scores for women above 40 years of age appeared to recover more rapidly and reached higher levels than those for women below 40 years (P = 0.03). Caution and extra care are recommended in the early period of cervical cancer treatment given the slight deterioration in the QoL, and in particular, for younger cervical cancer patients. Our study implies that health care providers may need to improve the health-related QoL of cervical cancer patients. |
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Keywords: | Cervical cancer cervical precursor lesion quality of life EQ-D prospective study Chinese women |
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