GM-CSF-Loaded Nanoparticles for Photothermal-Assisted Immunotherapy against Orthotopic Bladder Cancer |
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| Authors: | Weifeng Ren Xiaomeng Cai Jun Chen Lifo Ruan Huiru Lu Jiayu Zhang Yi Hu Jimin Gao |
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| Institution: | 1 Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, 325035, China2 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China3 University of Chinese Academy of Sciences, Beijing, 100049, China |
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| Abstract: | This study reported the construction of GM-CSF-loaded chitosan/graphene oxide nanoparticles for photothermal therapy-assisted immunotherapy against murine orthotopic bladder cancer. The encapsulated GM-CSF in chitosan/graphene oxide nanoparticles facilitated their immobilization on biotinylated mouse orthotopic bladder cancer surface, resulting in slow release of antitumor immune adjuvant. Locally released GM-CSF efficiently recruited dendritic cells to bladder tumor sites, thereby promoting immune responses in mice. Thus, the activated immune response in mice provided enhanced antitumor effects. Meanwhile, the thermal effect from the nanoparticles upon light irradiation induced a significant increase in dendritic cells and T cells compared with other groups, which confirmed that the focal photothermal effect potentiated antitumor immune response to tumors. |
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| Keywords: | Nanoparticles SA-mGM-CSF bladder cancer immunotherapy photothermal therapy |
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