长链非编码RNA与HIPPO通路相互作用在消化系统肿瘤中的研究进展#br#

【摘要】长链非编码RNA (lncRNA) 是一类长度超过200个核苷酸的非编码 RNA，在染色体修饰、转录调控以及转录后加工的水平调控基因的表达，从而影响肿瘤细胞的发生、发展。HIPPPO信号通路是一条进化上十分保守的信号通路，近年来被发现在调控细胞生长、凋亡及组织器官大小等方面起重要作用，且与肿瘤关系密切，lncRNA与HIPPO通路的相互作用对消化系统肿瘤的增殖、迁移、侵袭和耐药性等方面产生重要影响。文章对lncRNA与HIPPO通路在消化系统肿瘤中的相互作用机制进行总结，旨在为消化系统肿瘤的个体化治疗寻找新的治疗靶点。

The research progress of the crosstalk between long non-coding RNA and HIPPO signaling pathway in gastrointestinal carcinomas

Long non-coding RNAs (lncRNAs) are a type of non-coding RNA that comprises of nucleotide（nt）sequences longer than 200 nts. Considerable studies have shown that the aberrant expression and dysregulation of lncRNAs are widely implicated in cancer initiation and progression by acting as tumour promoters or suppressors. Hippo signaling pathway has attracted researchers’ attention as one of the critical cancer-related pathways in recent years. Increasing evidences have demonstrated that lncRNAs could interact with Hippo signaling pathway and thereby contribute to acquisition of multiple malignant hallmarks, including proliferation, metastasis, relapse and resistance to anti-cancer treatment. This review focuses on the crosstalk between lncRNAs and Hippo signaling pathway in gastrointestinal cancers.