介导肿瘤细胞G2期周期阻滞的分子机制

肿瘤的形成与进展离不开肿瘤细胞中细胞周期调控蛋白的改变,利用肿瘤细胞的G2-M期周期阻滞效应在减缓肿瘤的生长、提高治疗疗效方面尤为重要.DNA损伤的感受器、信号传导因子和效应器是介导肿瘤细胞G2期周期阻滞的经典途径,且有作为新型肿瘤治疗靶点的可能.

Molecular mechanism of G2 phase cell cycle arrest in tumor cells

The formation and progression of tumor is inseparable from the changes of cell cycle regulatory proteins.The G2-M period block effect of tumor cells is especially important in slowing the growth of tumor and improving the curative effect.DNA damage receptor,signal transduction factor and effectors are the classical pathways to mediate G2 phase arrest of tumor cells,and have the potential to be new targets for tumor therapy.