核孔蛋白与肿瘤

在真核生物中,细胞的物质交换在其增殖和凋亡中长期存在,而细胞核与质的交换只能通过核孔复合体(NPC)进行的穿梭运动实现.NPC位于细胞核膜,通过穿梭运动实现真核生物中核与质之间蛋白、RNA等物质的运输任务.特定的核孔蛋白会调节特定的运输路径,而正是由于此,通过NPC进行的运输和调节是高选择性和协调性,从而使NPC在基因表达、信号网络和保持细胞内环境中起到了重要作用.它们当中有的会改变核膜的结构性状,影响有丝分裂,有的可以通过与激酶结合导致异常的生化反应,或者与其他生物因子作用,在血管生成、细胞迁移或者细胞生成及凋亡的环节出现异常变化,从而导致肿瘤的发生.

Nucleoporin and tumor

In eukaryotes, the cell’s material exchange has long existed in its proliferation and apoptosis, while the exchange of nucleus and cytoplasm only through the shuttle movement of the nuclear pore complex (NPC). NPC in the nuclear membrane, achieves the protein, RNA and other substances’s transport task through the shuttle movement between nucleus and cytoplasm of eukaryotes. Specific nuclear pore proteins regulate specific transport path, and because of this, the transport and regulation through the NPC is highly selective and coordination, so the NPC play an important role in gene expression, cell signaling networks and maintain the environment. Some of them will change the structure properties of membrane, affecting mitosis, and some can be combined with the kinase leading to abnormal biochemical reactions, or combined with other biological factors in angiogenesis, cell migration or apoptosis of cells leading to abnormal changes, and leading to tumorigenesis.